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Penicillin skin test kit
A penicillin skin test kit detects IgE-mediated allergic sensitization to penicillin by introducing penicillin antigen intradermally and observing for a wheal-and-flare reaction.
A penicillin skin test kit detects IgE-mediated allergic sensitization to penicillin by introducing penicillin antigen intradermally and observing for a wheal-and-flare reaction. Used for Detection of IgE-mediated penicillin allergy in patients with reported penicillin hypersensitivity.
At a glance
| Generic name | Penicillin skin test kit |
|---|---|
| Also known as | PRE-PEN (benzylpenicilloyl polylysine), MDM (minor determinant mixture of penicillins), benzylpenicillin, benzylpenicilloate, benzylpenilloate |
| Sponsor | AllerQuest LLC |
| Drug class | Diagnostic test kit / Allergen extract |
| Modality | Small molecule |
| Therapeutic area | Allergy / Immunology |
| Phase | Phase 3 |
Mechanism of action
The kit uses penicillin G and penicilloyl polylysine (PPL) as test antigens applied via scratch or intradermal injection. In penicillin-sensitized individuals, cross-linking of IgE on mast cells triggers immediate degranulation, releasing histamine and other mediators that produce a localized wheal-and-flare response within 15–20 minutes. This reaction indicates IgE-mediated penicillin allergy and helps guide safe antibiotic selection.
Approved indications
- Detection of IgE-mediated penicillin allergy in patients with reported penicillin hypersensitivity
Common side effects
- Localized wheal and erythema at test site
- Pruritus at test site
- Systemic allergic reaction (rare)
Key clinical trials
- Evaluation of Skin Testing Reagents for Penicillin Allergy (PHASE3)
- Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Penicillin skin test kit CI brief — competitive landscape report
- Penicillin skin test kit updates RSS · CI watch RSS
- AllerQuest LLC portfolio CI