{"id":"penicillin-skin-test-kit","safety":{"commonSideEffects":[{"rate":null,"effect":"Localized wheal and erythema at test site"},{"rate":null,"effect":"Pruritus at test site"},{"rate":null,"effect":"Systemic allergic reaction (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The kit uses penicillin G and penicilloyl polylysine (PPL) as test antigens applied via scratch or intradermal injection. In penicillin-sensitized individuals, cross-linking of IgE on mast cells triggers immediate degranulation, releasing histamine and other mediators that produce a localized wheal-and-flare response within 15–20 minutes. This reaction indicates IgE-mediated penicillin allergy and helps guide safe antibiotic selection.","oneSentence":"A penicillin skin test kit detects IgE-mediated allergic sensitization to penicillin by introducing penicillin antigen intradermally and observing for a wheal-and-flare reaction.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:44.149Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Detection of IgE-mediated penicillin allergy in patients with reported penicillin hypersensitivity"}]},"trialDetails":[{"nctId":"NCT01818336","phase":"PHASE3","title":"Evaluation of Skin Testing Reagents for Penicillin Allergy","status":"COMPLETED","sponsor":"AllerQuest LLC","startDate":"2012-12","conditions":"History of IgE Dependent Reaction to a Penicillin Product","enrollment":481},{"nctId":"NCT00789217","phase":"NA","title":"Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams","status":"COMPLETED","sponsor":"Chulalongkorn University","startDate":"2008-12","conditions":"Penicillin Allergy","enrollment":63}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["PRE-PEN (benzylpenicilloyl polylysine)","MDM (minor determinant mixture of penicillins)","benzylpenicillin","benzylpenicilloate","benzylpenilloate"],"phase":"phase_3","status":"active","brandName":"Penicillin skin test kit","genericName":"Penicillin skin test kit","companyName":"AllerQuest LLC","companyId":"allerquest-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A penicillin skin test kit detects IgE-mediated allergic sensitization to penicillin by introducing penicillin antigen intradermally and observing for a wheal-and-flare reaction. Used for Detection of IgE-mediated penicillin allergy in patients with reported penicillin hypersensitivity.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}