Last reviewed · How we verify
PENG block and cryoablation
PENG block is a regional anesthesia technique that combines a peripheral nerve block with cryoablation to provide prolonged pain relief by freezing nerve tissue.
The University of Minnesota is investigating the use of PENG block and cryoablation for pain management in patients with hip fractures. This Phase 4 trial compares the efficacy and safety of PENG block and cryoablation to the Fascia Iliaca Catheter, aiming to improve postoperative pain control and reduce opioid use.
At a glance
| Generic name | PENG block and cryoablation |
|---|---|
| Sponsor | University of Minnesota |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Anesthesia |
| Phase | FDA-approved |
Mechanism of action
PENG (Pectineus Compartment) block targets the obturator and femoral nerves in the pectineus compartment, and when combined with cryoablation (controlled freezing of nerve tissue), it creates a longer-lasting analgesic effect than traditional nerve blocks alone. This combination approach is used perioperatively and for chronic pain management to reduce opioid requirements and improve patient outcomes.
Approved indications
- Perioperative pain management for hip and groin surgery
- Chronic hip and groin pain management
Common side effects
- Nerve injury
- Hematoma
- Infection at injection site
- Temporary motor weakness
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |