{"id":"peng-block-and-cryoablation","brandName":"PENG block and cryoablation","genericName":"PENG block and cryoablation","companyId":"university-of-minnesota","companyName":"University of Minnesota","phase":"marketed","status":"active","modality":"Small molecule","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"The University of Minnesota is investigating the use of PENG block and cryoablation for pain management in patients with hip fractures. This Phase 4 trial compares the efficacy and safety of PENG block and cryoablation to the Fascia Iliaca Catheter, aiming to improve postoperative pain control and reduce opioid use.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PENG (Pectineus Compartment) block targets the obturator and femoral nerves in the pectineus compartment, and when combined with cryoablation (controlled freezing of nerve tissue), it creates a longer-lasting analgesic effect than traditional nerve blocks alone. This combination approach is used perioperatively and for chronic pain management to reduce opioid requirements and improve patient outcomes.","oneSentence":"PENG block is a regional anesthesia technique that combines a peripheral nerve block with cryoablation to provide prolonged pain relief by freezing nerve tissue.","_ai_confidence":"low"},"administration":{},"safety":{"commonSideEffects":[{"rate":null,"effect":"Nerve injury"},{"rate":null,"effect":"Hematoma"},{"rate":null,"effect":"Infection at injection site"},{"rate":null,"effect":"Temporary motor weakness"}]},"trials":[],"indications":{"approved":[{"name":"Perioperative pain management for hip and groin surgery"},{"name":"Chronic hip and groin pain management"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[{"nctId":"NCT06278987","phase":"PHASE4","title":"Comparison of Cryoablation of Pericapsular Nerve Group (PENG) to Fascia Iliaca Catheter in Patients With a Hip Fracture","status":"RECRUITING","sponsor":"University of Minnesota","startDate":"2024-10-01","conditions":["Hip Fractures"],"enrollment":150,"completionDate":"2027-10-01"}],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}