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PEG then Senna
PEG (polyethylene glycol) followed by Senna works as a bowel preparation regimen that uses an osmotic laxative to cleanse the colon, followed by a stimulant laxative to promote evacuation.
PEG (polyethylene glycol) followed by Senna works as a bowel preparation regimen that uses an osmotic laxative to cleanse the colon, followed by a stimulant laxative to promote evacuation. Used for Bowel preparation prior to colonoscopy or other colorectal procedures, Bowel cleansing in cancer patients undergoing treatment.
At a glance
| Generic name | PEG then Senna |
|---|---|
| Also known as | Lax-a-Day |
| Sponsor | British Columbia Cancer Agency |
| Drug class | Laxative combination (osmotic + stimulant) |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
PEG is an osmotic laxative that draws water into the intestinal lumen to soften stool and promote bowel movements without being absorbed systemically. Senna is a stimulant laxative containing anthraquinone compounds that increase colonic motility and secretion. This sequential combination is used to achieve complete bowel cleansing, typically for diagnostic or procedural purposes.
Approved indications
- Bowel preparation prior to colonoscopy or other colorectal procedures
- Bowel cleansing in cancer patients undergoing treatment
Common side effects
- Abdominal cramping
- Nausea
- Bloating
- Diarrhea
Key clinical trials
- Polyethylene Glycol (PEG) Versus Sennosides Study in Opioid-Induced Constipation in Cancer Patients (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- PEG then Senna CI brief — competitive landscape report
- PEG then Senna updates RSS · CI watch RSS
- British Columbia Cancer Agency portfolio CI