{"id":"peg-then-senna","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal cramping"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Bloating"},{"rate":null,"effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PEG is an osmotic laxative that draws water into the intestinal lumen to soften stool and promote bowel movements without being absorbed systemically. Senna is a stimulant laxative containing anthraquinone compounds that increase colonic motility and secretion. This sequential combination is used to achieve complete bowel cleansing, typically for diagnostic or procedural purposes.","oneSentence":"PEG (polyethylene glycol) followed by Senna works as a bowel preparation regimen that uses an osmotic laxative to cleanse the colon, followed by a stimulant laxative to promote evacuation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:00:15.801Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel preparation prior to colonoscopy or other colorectal procedures"},{"name":"Bowel cleansing in cancer patients undergoing treatment"}]},"trialDetails":[{"nctId":"NCT01189409","phase":"PHASE4","title":"Polyethylene Glycol (PEG) Versus Sennosides Study in Opioid-Induced Constipation in Cancer Patients","status":"TERMINATED","sponsor":"British Columbia Cancer Agency","startDate":"2010-06","conditions":"Constipation, Cancer","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Lax-a-Day"],"phase":"marketed","status":"active","brandName":"PEG then Senna","genericName":"PEG then Senna","companyName":"British Columbia Cancer Agency","companyId":"british-columbia-cancer-agency","modality":"Small molecule","firstApprovalDate":"","aiSummary":"PEG (polyethylene glycol) followed by Senna works as a bowel preparation regimen that uses an osmotic laxative to cleanse the colon, followed by a stimulant laxative to promote evacuation. Used for Bowel preparation prior to colonoscopy or other colorectal procedures, Bowel cleansing in cancer patients undergoing treatment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}