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PEG/electrolytes 2L/2L split dose
PEG/electrolytes solution acts as an osmotic laxative that draws water into the bowel lumen to promote bowel evacuation.
PEG/electrolytes solution acts as an osmotic laxative that draws water into the bowel lumen to promote bowel evacuation. Used for Bowel cleansing prior to colonoscopy, Bowel cleansing prior to other gastrointestinal procedures.
At a glance
| Generic name | PEG/electrolytes 2L/2L split dose |
|---|---|
| Sponsor | McGill University Health Centre/Research Institute of the McGill University Health Centre |
| Drug class | Osmotic laxative |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Polyethylene glycol (PEG) is a non-absorbable osmotic agent that retains water in the intestinal lumen, increasing stool bulk and promoting peristalsis. The electrolyte component (sodium chloride, potassium chloride, sodium bicarbonate, sodium sulfate) maintains electrolyte balance and prevents net fluid absorption or secretion. The split-dose regimen (2L the evening before and 2L the morning of procedure) optimizes bowel cleansing while improving patient tolerability.
Approved indications
- Bowel preparation prior to colonoscopy
- Bowel preparation prior to other gastrointestinal procedures
Common side effects
- Nausea
- Abdominal bloating
- Abdominal cramping
- Vomiting
- Anal irritation
Key clinical trials
- Comparison of Split-dose and Single-dose Bowel Preparation Regimens Using Polyethylene Glycol Electrolyte(PEG) (NA)
- Colon Preparation With 2L PEG in Combination With Lubiprostone vs 4L PEG (PHASE4)
- Comparison of Two Types of Bowel Preparation for Inpatient Colonoscopy (PHASE4)
- Patient Tolerability and Efficacy of Bowel Preparation With Split Dose Picosalax vs. Split Dose PEG (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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