{"id":"peg-electrolytes-2l-2l-split-dose","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Nausea"},{"rate":"15-25","effect":"Abdominal bloating"},{"rate":"10-20","effect":"Abdominal cramping"},{"rate":"5-10","effect":"Vomiting"},{"rate":"5-15","effect":"Anal irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Polyethylene glycol (PEG) is a non-absorbable osmotic agent that retains water in the intestinal lumen, increasing stool bulk and promoting peristalsis. The electrolyte component (sodium chloride, potassium chloride, sodium bicarbonate, sodium sulfate) maintains electrolyte balance and prevents net fluid absorption or secretion. The split-dose regimen (2L the evening before and 2L the morning of procedure) optimizes bowel cleansing while improving patient tolerability.","oneSentence":"PEG/electrolytes solution acts as an osmotic laxative that draws water into the bowel lumen to promote bowel evacuation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:00:09.790Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel preparation prior to colonoscopy"},{"name":"Bowel preparation prior to other gastrointestinal procedures"}]},"trialDetails":[{"nctId":"NCT06551883","phase":"NA","title":"Comparison of Split-dose and Single-dose Bowel Preparation Regimens Using Polyethylene Glycol Electrolyte(PEG)","status":"COMPLETED","sponsor":"Tongji Hospital","startDate":"2021-01-01","conditions":"Bowel Preparation","enrollment":101},{"nctId":"NCT04138004","phase":"PHASE4","title":"Colon Preparation With 2L PEG in Combination With Lubiprostone vs 4L PEG","status":"COMPLETED","sponsor":"Department of Medical Services Ministry of Public Health of Thailand","startDate":"2019-12-01","conditions":"Indication for Modification of Patient Status (Diagnosis)","enrollment":140},{"nctId":"NCT02119000","phase":"PHASE4","title":"Comparison of Two Types of Bowel Preparation for Inpatient Colonoscopy","status":"TERMINATED","sponsor":"McGill University Health Centre/Research Institute of the McGill University Health Centre","startDate":"2015-08","conditions":"Hospitalized Patients","enrollment":82},{"nctId":"NCT02070341","phase":"PHASE4","title":"Patient Tolerability and Efficacy of Bowel Preparation With Split Dose Picosalax vs. Split Dose PEG","status":"TERMINATED","sponsor":"Queen's University","startDate":"2014-02","conditions":"Bowel Preparation","enrollment":5}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"PEG/electrolytes 2L/2L split dose","genericName":"PEG/electrolytes 2L/2L split dose","companyName":"McGill University Health Centre/Research Institute of the McGill University Health Centre","companyId":"mcgill-university-health-centre-research-institute-of-the-mcgill-university-heal","modality":"Small molecule","firstApprovalDate":"","aiSummary":"PEG/electrolytes solution acts as an osmotic laxative that draws water into the bowel lumen to promote bowel evacuation. Used for Bowel cleansing prior to colonoscopy, Bowel cleansing prior to other gastrointestinal procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}