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PEG-Asc with simethicone
PEG-Asc with simethicone is a bowel preparation combining polyethylene glycol-ascorbic acid for osmotic laxation with simethicone to reduce gas and bloating during colonoscopy preparation.
PEG-Asc with simethicone is a bowel preparation combining polyethylene glycol-ascorbic acid for osmotic laxation with simethicone to reduce gas and bloating during colonoscopy preparation. Used for Bowel preparation prior to colonoscopy.
At a glance
| Generic name | PEG-Asc with simethicone |
|---|---|
| Also known as | Coolprep with gasocol® ; TaeJoon Pharmaceuticals, Korea |
| Sponsor | Korea University Anam Hospital |
| Drug class | Bowel preparation agent / Osmotic laxative |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | Phase 3 |
Mechanism of action
PEG-Asc (polyethylene glycol with ascorbic acid) works as an osmotic laxative that draws water into the bowel to promote evacuation, while ascorbic acid reduces the volume needed compared to standard PEG solutions. Simethicone is an anti-foaming agent that breaks down gas bubbles in the colon, improving visualization during endoscopy and reducing patient discomfort.
Approved indications
- Bowel preparation prior to colonoscopy
Common side effects
- Nausea
- Abdominal bloating
- Abdominal cramping
- Vomiting
Key clinical trials
- Effect of Simethicone on Bowel Preparation for Colonoscopy (PHASE3)
- Different Bowel Preparations for Colonoscopy In Children (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- PEG-Asc with simethicone CI brief — competitive landscape report
- PEG-Asc with simethicone updates RSS · CI watch RSS
- Korea University Anam Hospital portfolio CI