{"id":"peg-asc-with-simethicone","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Abdominal bloating"},{"rate":null,"effect":"Abdominal cramping"},{"rate":null,"effect":"Vomiting"}]},"_chembl":{"chemblId":"CHEMBL4297192","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PEG-Asc (polyethylene glycol with ascorbic acid) works as an osmotic laxative that draws water into the bowel to promote evacuation, while ascorbic acid reduces the volume needed compared to standard PEG solutions. Simethicone is an anti-foaming agent that breaks down gas bubbles in the colon, improving visualization during endoscopy and reducing patient discomfort.","oneSentence":"PEG-Asc with simethicone is a bowel preparation combining polyethylene glycol-ascorbic acid for osmotic laxation with simethicone to reduce gas and bloating during colonoscopy preparation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:26:05.894Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel preparation prior to colonoscopy"}]},"trialDetails":[{"nctId":"NCT02548403","phase":"PHASE3","title":"Effect of Simethicone on Bowel Preparation for Colonoscopy","status":"COMPLETED","sponsor":"Korea University Anam Hospital","startDate":"2014-07","conditions":"Colorectal Cancer","enrollment":260},{"nctId":"NCT01711437","phase":"PHASE4","title":"Different Bowel Preparations for Colonoscopy In Children","status":"UNKNOWN","sponsor":"Azienda Policlinico Umberto I","startDate":"2011-01","conditions":"Colonoscopy","enrollment":400}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Coolprep with gasocol® ; TaeJoon Pharmaceuticals, Korea"],"phase":"phase_3","status":"active","brandName":"PEG-Asc with simethicone","genericName":"PEG-Asc with simethicone","companyName":"Korea University Anam Hospital","companyId":"korea-university-anam-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"PEG-Asc with simethicone is a bowel preparation combining polyethylene glycol-ascorbic acid for osmotic laxation with simethicone to reduce gas and bloating during colonoscopy preparation. Used for Bowel preparation prior to colonoscopy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}