Last reviewed · How we verify
Paravertebral block using local anesthetic
A paravertebral block uses injected local anesthetic to reversibly block nerve conduction in the paravertebral space, numbing a specific region of the body.
A paravertebral block uses injected local anesthetic to reversibly block nerve conduction in the paravertebral space, numbing a specific region of the body. Used for Perioperative anesthesia and analgesia for thoracic and abdominal surgery, Postoperative pain management, Chronic pain conditions affecting the thorax and abdomen.
At a glance
| Generic name | Paravertebral block using local anesthetic |
|---|---|
| Sponsor | University of Wisconsin, Madison |
| Drug class | Local anesthetic regional nerve block |
| Target | Voltage-gated sodium channels (non-selective) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Local anesthetic agents (such as lidocaine or bupivacaine) are deposited in the paravertebral space adjacent to the vertebral column, where they diffuse to nearby spinal nerves and block sodium channels in nerve membranes. This prevents action potential propagation along sensory and motor nerves, producing regional anesthesia and analgesia in the distribution of the blocked nerves. The effect is temporary and resolves as the anesthetic is metabolized and redistributed.
Approved indications
- Regional anesthesia for thoracic and abdominal surgical procedures
- Postoperative pain management
- Chronic pain conditions (e.g., post-thoracotomy pain syndrome)
Common side effects
- Local anesthetic toxicity (systemic)
- Pneumothorax
- Vascular puncture/hematoma
- Nerve injury
- Hypotension
- Bradycardia
Key clinical trials
- Parascapular Sub Iliocostalis Plane Block Versus Thoracic Paravertebral Plane Block for Traumatic Multiple Rib Fractures (NA)
- Study of Nerve Block Pain Management in Patients Undergoing a Double Mastectomy With Immediate Reconstruction (PHASE4)
- Sensory Anesthesia Achieved Through Different Paravertebral Block Approaches for Post-Op Pain Management After VATS Lung Resection
- Comparison of the Postoperative Analgesic Effects of SPSIPB and TPB in Mastectomy Operations (NA)
- Tubeless Strategy for Enhanced Recovery After Sublobar Resection (NA)
- Non-intubated Versus Intubated Anesthesia for Thoracoscopic Sublobar Resection (NA)
- Ultrasound-Guided Thoracic Paravertebral Block With Steroid and Local Anesthetic for Acute Herpes Zoster: Effects on Pain Control and Prevention of Postherpetic Neuralgia (PHASE3)
- Erector Spınae Plane Block and Transmuscular Quadratus Lumborum Block In Kıdney Transplantatıon (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: