{"id":"paravertebral-block-using-local-anesthetic","safety":{"commonSideEffects":[{"rate":null,"effect":"Local anesthetic toxicity (systemic)"},{"rate":"0.5–1%","effect":"Pneumothorax"},{"rate":null,"effect":"Vascular puncture/hematoma"},{"rate":"rare","effect":"Nerve injury"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Local anesthetic agents (such as lidocaine or bupivacaine) are deposited in the paravertebral space adjacent to the vertebral column, where they diffuse to nearby spinal nerves and block sodium channels in nerve membranes. This prevents action potential propagation along sensory and motor nerves, producing regional anesthesia and analgesia in the distribution of the blocked nerves. The effect is temporary and resolves as the anesthetic is metabolized and redistributed.","oneSentence":"A paravertebral block uses injected local anesthetic to reversibly block nerve conduction in the paravertebral space, numbing a specific region of the body.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:59:46.917Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Regional anesthesia for thoracic and abdominal surgical procedures"},{"name":"Postoperative pain management"},{"name":"Chronic pain conditions (e.g., post-thoracotomy pain syndrome)"}]},"trialDetails":[{"nctId":"NCT07493473","phase":"NA","title":"Parascapular Sub Iliocostalis Plane Block Versus Thoracic Paravertebral Plane Block for Traumatic Multiple Rib Fractures","status":"ACTIVE_NOT_RECRUITING","sponsor":"Zagazig University","startDate":"2025-05-01","conditions":"Discitis of Thoracic Region","enrollment":36},{"nctId":"NCT04016376","phase":"PHASE4","title":"Study of Nerve 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numbing a specific region of the body. Used for Perioperative anesthesia and analgesia for thoracic and abdominal surgery, Postoperative pain management, Chronic pain conditions affecting the thorax and abdomen.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}