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paracetamol /droperidol
Paracetamol reduces pain and fever through inhibition of prostaglandin synthesis, while droperidol is an antipsychotic and antiemetic that blocks dopamine receptors.
Paracetamol reduces pain and fever through inhibition of prostaglandin synthesis, while droperidol is an antipsychotic and antiemetic that blocks dopamine receptors. Used for Acute pain management with nausea/vomiting prevention.
At a glance
| Generic name | paracetamol /droperidol |
|---|---|
| Sponsor | University Hospital, Limoges |
| Drug class | Analgesic/Antipyretic combined with Antipsychotic/Antiemetic |
| Target | Cyclooxygenase (COX) enzymes; Dopamine D2 receptor |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Acute Care |
| Phase | Phase 3 |
Mechanism of action
This is a combination drug pairing paracetamol (acetaminophen), which works centrally to inhibit cyclooxygenase enzymes and reduce prostaglandin production, with droperidol, a butyrophenone antipsychotic that antagonizes dopamine D2 receptors to provide antiemetic and sedative effects. The combination is designed to provide analgesia with antiemetic and anxiolytic benefits, particularly useful in acute pain management settings.
Approved indications
- Acute pain management with nausea/vomiting prevention
Common side effects
- Sedation
- Hypotension
- Extrapyramidal symptoms
- Hepatotoxicity (paracetamol)
Key clinical trials
- E7 TCR T Cells for Human Papillomavirus-Associated Cancers (PHASE1, PHASE2)
- Supra Inguinal Fascia Iliaca Block as Rescue Analgesia Following Total Hip Arthroplasty (NA)
- Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair (PHASE4)
- Lumbar Erector Spinae Plane Block for Back Surgery (PHASE3)
- Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC (PHASE4)
- A Fast-track Versus Conventional Recovery Protocol in Laparoscopic Hysterctomy (NA)
- Antagonism Research Between Antiemetics Agents and Acetaminophen in Thyroidectomy's Post-operative Analgesia. (PHASE3)
- Study of Anesthesia Techniques to Reduce Nausea and Vomiting After Jaw Corrective Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- paracetamol /droperidol CI brief — competitive landscape report
- paracetamol /droperidol updates RSS · CI watch RSS
- University Hospital, Limoges portfolio CI