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Paracetamol +caudal ropivacaine
Paracetamol reduces pain and fever through central inhibition of prostaglandin synthesis, while caudal ropivacaine provides local anesthetic blockade of nerve conduction in the sacral region.
Paracetamol reduces pain and fever through central inhibition of prostaglandin synthesis, while caudal ropivacaine provides local anesthetic blockade of nerve conduction in the sacral region. Used for Perioperative pain management in pediatric and adult patients undergoing lower abdominal, pelvic, or lower limb surgery, Acute postoperative pain relief.
At a glance
| Generic name | Paracetamol +caudal ropivacaine |
|---|---|
| Sponsor | Aga Khan University |
| Drug class | Analgesic combination (systemic + local anesthetic) |
| Target | COX inhibition (paracetamol); voltage-gated sodium channels (ropivacaine) |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Anesthesia |
| Phase | FDA-approved |
Mechanism of action
This is a combination therapy: paracetamol (acetaminophen) acts as a systemic analgesic and antipyretic by inhibiting cyclooxygenase enzymes in the central nervous system. Caudal ropivacaine is a local anesthetic administered via caudal epidural injection that blocks sodium channels in nerve fibers, providing regional anesthesia and analgesia in the lower body and pelvic region. Together, they provide multimodal pain control for perioperative or acute pain management.
Approved indications
- Perioperative pain management in pediatric and adult patients undergoing lower abdominal, pelvic, or lower limb surgery
- Acute postoperative pain relief
Common side effects
- Hepatotoxicity (paracetamol, dose-dependent)
- Local anesthetic toxicity (ropivacaine)
- Hypotension
- Bradycardia
- Urinary retention
- Nausea
Key clinical trials
- Regional Anesthesia by PENG-Block in Emergency Department (NA)
- Supra Inguinal Fascia Iliaca Block as Rescue Analgesia Following Total Hip Arthroplasty (NA)
- Intravenous Paracetamol in Combination With Caudal Ropivacaine (PHASE4)
- Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair (NA)
- Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Hernia Repair (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |