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paracetamol + caffeine
Paracetamol acts as a non-selective inhibitor of COX enzymes, reducing prostaglandin synthesis and thereby decreasing pain and fever, while caffeine acts as a stimulant and analgesic.
Paracetamol acts as a non-selective inhibitor of COX enzymes, reducing prostaglandin synthesis and thereby decreasing pain and fever, while caffeine acts as a stimulant and analgesic. Used for Relief of mild to moderate pain, Reduction of fever.
At a glance
| Generic name | paracetamol + caffeine |
|---|---|
| Sponsor | GlaxoSmithKline |
| Drug class | Analgesic |
| Target | COX enzymes |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | Phase 3 |
Mechanism of action
Paracetamol's mechanism of action is not fully understood, but it is thought to involve the inhibition of COX enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins are mediators of pain and inflammation, and by reducing their synthesis, paracetamol is able to decrease pain and fever. Caffeine, on the other hand, acts as a stimulant and analgesic by blocking adenosine receptors in the brain, which can help to increase alertness and reduce pain perception.
Approved indications
- Relief of mild to moderate pain
- Reduction of fever
Common side effects
- Nausea
- Headache
- Dizziness
- Insomnia
Key clinical trials
- Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)
- Assessment of Oral Caffeine Intake in Changing the Severity of Acute Migraine Attack Using VAS Score Among Patients Attending Headache and Neurology Outpatients Clinic of Ainshams University Hospitals (PHASE4)
- A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After Dental Surgeries Compared to the Single Ingredients and to Placebo (PHASE3)
- Nebulized Dexmedetomidine or Lidocaine for Treatment of Post Dural Puncture Headache in Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia (EARLY_PHASE1)
- Paracetamol-Tramadol and Paracetamol-caffeine Versus Placebo in the Emergency Discharge Treatment of Renal Colic (PHASE2)
- Awake Caudal Catheter vs General Anesthesia (PHASE4)
- Acute Headache Treatment in Pregnancy: Occipital Nerve Block vs PO Acetaminophen With Caffeine (PHASE4)
- Management of Post Dural Pucture Headache After Lower Limb Surgeries: Oral Prednisolone vs Oral Pregabalin (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- paracetamol + caffeine CI brief — competitive landscape report
- paracetamol + caffeine updates RSS · CI watch RSS
- GlaxoSmithKline portfolio CI