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Caffeine, on the other hand, acts as a stimulant and analgesic by blocking adenosine receptors in the brain, which can help to increase alertness and reduce pain perception.","oneSentence":"Paracetamol acts as a non-selective inhibitor of COX enzymes, reducing prostaglandin synthesis and thereby decreasing pain and fever, while caffeine acts as a stimulant and analgesic.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:25:38.160Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Relief of mild to moderate pain"},{"name":"Reduction of fever"}]},"trialDetails":[{"nctId":"NCT05055830","phase":"","title":"Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)","status":"RECRUITING","sponsor":"Duke University","startDate":"2021-10-05","conditions":"Cardiac Disease, Critically Ill, Children, Adult","enrollment":2000},{"nctId":"NCT07022496","phase":"PHASE4","title":"Assessment of Oral Caffeine Intake in Changing the Severity of Acute Migraine 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