Last reviewed · How we verify
Paracetamol and glycerol
Paracetamol reduces fever and pain through inhibition of prostaglandin synthesis, while glycerol acts as a osmotic agent and humectant to improve drug delivery and formulation stability.
Paracetamol reduces fever and pain through inhibition of prostaglandin synthesis, while glycerol acts as a osmotic agent and humectant to improve drug delivery and formulation stability. Used for Fever reduction, Mild to moderate pain relief.
At a glance
| Generic name | Paracetamol and glycerol |
|---|---|
| Sponsor | Kamuzu University of Health Sciences |
| Drug class | Analgesic/antipyretic combination formulation |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Fever Reduction |
| Phase | Phase 3 |
Mechanism of action
Paracetamol (acetaminophen) works by inhibiting cyclooxygenase enzymes in the central nervous system, reducing prostaglandin production and thereby lowering pain perception and body temperature. Glycerol serves as an excipient that enhances bioavailability, acts as a humectant to maintain moisture, and may provide osmotic effects to improve absorption and therapeutic efficacy of the paracetamol component.
Approved indications
- Fever reduction
- Mild to moderate pain relief
Common side effects
- Hepatotoxicity (at high doses)
- Nausea
- Rash
- Gastrointestinal upset
Key clinical trials
- Diet Oil Induced Stimulation of GLP-1 (EARLY_PHASE1)
- Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |