{"id":"paracetamol-and-glycerol","safety":{"commonSideEffects":[{"rate":null,"effect":"Hepatotoxicity (at high doses)"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Gastrointestinal upset"}]},"_chembl":{"chemblId":"CHEMBL5592090","moleculeType":null,"molecularWeight":"152.15"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Paracetamol (acetaminophen) works by inhibiting cyclooxygenase enzymes in the central nervous system, reducing prostaglandin production and thereby lowering pain perception and body temperature. Glycerol serves as an excipient that enhances bioavailability, acts as a humectant to maintain moisture, and may provide osmotic effects to improve absorption and therapeutic efficacy of the paracetamol component.","oneSentence":"Paracetamol reduces fever and pain through inhibition of prostaglandin synthesis, while glycerol acts as a osmotic agent and humectant to improve drug delivery and formulation stability.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:25:38.903Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fever reduction"},{"name":"Mild to moderate pain relief"}]},"trialDetails":[{"nctId":"NCT01453842","phase":"EARLY_PHASE1","title":"Diet Oil Induced Stimulation of GLP-1","status":"COMPLETED","sponsor":"University of Copenhagen","startDate":"2011-03","conditions":"Type 2 Diabetes Mellitus","enrollment":12},{"nctId":"NCT00619203","phase":"PHASE3","title":"Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis","status":"COMPLETED","sponsor":"Kamuzu University of Health Sciences","startDate":"2008-03","conditions":"Bacterial Meningitis","enrollment":466}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Paracetamol and glycerol","genericName":"Paracetamol and glycerol","companyName":"Kamuzu University of Health Sciences","companyId":"kamuzu-university-of-health-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Paracetamol reduces fever and pain through inhibition of prostaglandin synthesis, while glycerol acts as a osmotic agent and humectant to improve drug delivery and formulation stability. Used for Fever reduction, Mild to moderate pain relief.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}