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Paracervical Nerve Block
A paracervical nerve block is a local anesthetic injection administered around the cervix to block pain signals during gynecological procedures.
A paracervical nerve block is a local anesthetic injection administered around the cervix to block pain signals during gynecological procedures. Used for Pain management during gynecological procedures (dilation and curettage, hysterosalpingography, cervical procedures), Pediatric gynecological procedures at Children's Hospital of Philadelphia.
At a glance
| Generic name | Paracervical Nerve Block |
|---|---|
| Also known as | 1 % Lidocaine |
| Sponsor | Children's Hospital of Philadelphia |
| Drug class | Local anesthetic nerve block |
| Modality | Small molecule |
| Therapeutic area | Gynecology/Pain Management |
| Phase | FDA-approved |
Mechanism of action
The procedure involves injecting local anesthetic (typically lidocaine or bupivacaine) into the tissue surrounding the cervix to anesthetize the paracervical nerves. This blocks pain transmission from the cervix and lower uterus during procedures such as dilation and curettage, IUD insertion, or other gynecological interventions. The block provides regional anesthesia without systemic sedation.
Approved indications
- Pain management during gynecological procedures (dilation and curettage, IUD insertion, cervical procedures)
- Pediatric gynecological procedures at Children's Hospital of Philadelphia
Common side effects
- Vasovagal response / syncope
- Uterine perforation (rare)
- Local anesthetic toxicity
- Infection at injection site
Key clinical trials
- Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement (PHASE2)
- Effect of Paracervical Block on Postoperative Pain After vNOTES Uterosacral Ligament Suspension (NA)
- Pipelle Versus Karman Endometrial Biopsy Under Standardized Paracervical Block (NA)
- 1% Lidocaine Paracervical Block for Endometrial Biopsy (NA)
- Comparison of Manual Vacuum Aspiration and Dilatation and Curettage for Endometrial Sampling Adequacy in Women With Abnormal Uterine Bleeding (NA)
- TENS Unit To Decrease Pain After Laminaria Insertion (NA)
- Combined Ketorolac and Lidocaine Paracervical Block for Office Hysteroscopy (PHASE1)
- Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Paracervical Nerve Block CI brief — competitive landscape report
- Paracervical Nerve Block updates RSS · CI watch RSS
- Children's Hospital of Philadelphia portfolio CI