{"id":"paracervical-nerve-block","safety":{"commonSideEffects":[{"rate":null,"effect":"Vasovagal response / syncope"},{"rate":null,"effect":"Uterine perforation (rare)"},{"rate":null,"effect":"Local anesthetic toxicity"},{"rate":null,"effect":"Infection at injection site"}]},"_chembl":{"chemblId":"CHEMBL4297796","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The procedure involves injecting local anesthetic (typically lidocaine or bupivacaine) into the tissue surrounding the cervix to anesthetize the paracervical nerves. This blocks pain transmission from the cervix and lower uterus during procedures such as dilation and curettage, IUD insertion, or other gynecological interventions. The block provides regional anesthesia without systemic sedation.","oneSentence":"A paracervical nerve block is a local anesthetic injection administered around the cervix to block pain signals during gynecological procedures.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:59:43.068Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pain management during gynecological procedures (dilation and curettage, IUD insertion, cervical procedures)"},{"name":"Pediatric gynecological procedures at Children's Hospital of Philadelphia"}]},"trialDetails":[{"nctId":"NCT07487246","phase":"PHASE2","title":"Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement","status":"NOT_YET_RECRUITING","sponsor":"Rush University Medical Center","startDate":"2026-05-01","conditions":"Pain Management, Abortion, Second Trimester Abortion","enrollment":76},{"nctId":"NCT07440576","phase":"NA","title":"Effect of Paracervical Block on 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Biopsy, Abnormal Uterine Bleeding","enrollment":120},{"nctId":"NCT02368054","phase":"PHASE4","title":"Hemodynamic Stability of Bupivacaine With and Without Adrenaline for Paracervical Block for Cervical Conization","status":"COMPLETED","sponsor":"Helse Fonna","startDate":"2015-05","conditions":"Cervical Intraepithelial Neoplasia","enrollment":34},{"nctId":"NCT02312739","phase":"NA","title":"Nitrous Oxide for Pain Management During In-office Transcervical Sterilization","status":"COMPLETED","sponsor":"University of New Mexico","startDate":"2014-02","conditions":"Contraception, Inhalation of Nitrous Oxide","enrollment":72},{"nctId":"NCT02096575","phase":"NA","title":"Nitrous Oxide for Pain Management of First Trimester Surgical Abortion","status":"COMPLETED","sponsor":"University of New Mexico","startDate":"2012-08","conditions":"Abortion in First Trimester","enrollment":140},{"nctId":"NCT01617564","phase":"NA","title":"Paracervical Block During II-trimester Abortion","status":"COMPLETED","sponsor":"Kristina Gemzell Danielsson","startDate":"2012-05","conditions":"Second Trimester Medical Abortion","enrollment":112},{"nctId":"NCT02416141","phase":"PHASE4","title":"Fast-release Orodispersible Tramadol as Analgesia in Termination of Pregnancy by Vacuum Aspiration.","status":"UNKNOWN","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2015-04","conditions":"Fertility","enrollment":128},{"nctId":"NCT02007408","phase":"NA","title":"Comparison of Lidocaine Spray and Paracervical Block Application for Pain Relief During First-trimester Surgical Abortion: a Randomized, Double-blind, Placebo-controlled Trial","status":"COMPLETED","sponsor":"Kayseri Education and Research Hospital","startDate":"2013-05","conditions":"Pain Score","enrollment":108},{"nctId":"NCT01947205","phase":"NA","title":"Pain and Suction Curettage","status":"COMPLETED","sponsor":"Gökhan Açmaz","startDate":"2012-11","conditions":"Curettage, Analgesia, Paracervical Block","enrollment":111},{"nctId":"NCT01207401","phase":"NA","title":"Paracervical Block Before Intrauterine Device (IUD) Insertion","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2010-07","conditions":"Pain Control for Intrauterine Device Insertions","enrollment":50},{"nctId":"NCT00318292","phase":"PHASE4","title":"Preemptive Local Anesthesia in Vaginal Surgery","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2006-04","conditions":"Pain, Postoperative","enrollment":90},{"nctId":"NCT01124383","phase":"NA","title":"The Impact of Anesthesia on the Absorption of Glycine in Operative Hysteroscopy: a Randomized Controlled Trial","status":"COMPLETED","sponsor":"CHU de Quebec-Universite Laval","startDate":"2008-08","conditions":"The Absorption of Glycine in Operative Hysteroscopy","enrollment":95},{"nctId":"NCT00733564","phase":"NA","title":"Evaluation of Different Anesthesia for Uterine Curettage","status":"COMPLETED","sponsor":"Nanjing Medical University","startDate":"2008-08","conditions":"Uterine Curettage, Abortion, Induced","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":20,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["1 % Lidocaine"],"phase":"marketed","status":"active","brandName":"Paracervical Nerve Block","genericName":"Paracervical Nerve Block","companyName":"Children's Hospital of Philadelphia","companyId":"children-s-hospital-of-philadelphia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A paracervical nerve block is a local anesthetic injection administered around the cervix to block pain signals during gynecological procedures. Used for Pain management during gynecological procedures (dilation and curettage, hysterosalpingography, cervical procedures), Pediatric gynecological procedures at Children's Hospital of Philadelphia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}