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Orotracheal Lidocaine Oral Spray application
Lidocaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and conduction of nerve impulses to produce local anesthesia.
Lidocaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and conduction of nerve impulses to produce local anesthesia. Used for Topical anesthesia of the oropharynx prior to intubation and other oropharyngeal procedures.
At a glance
| Generic name | Orotracheal Lidocaine Oral Spray application |
|---|---|
| Sponsor | Abant Izzet Baysal University |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Pain Management |
| Phase | FDA-approved |
Mechanism of action
Lidocaine works by reversibly inhibiting sodium influx through voltage-gated sodium channels in the neuronal membrane, which stabilizes the membrane and raises the threshold for electrical excitability. When applied topically as an oral spray, it anesthetizes the oropharyngeal mucosa and surrounding tissues, providing rapid onset of local anesthesia. This effect is useful for reducing discomfort during intubation procedures and other oropharyngeal interventions.
Approved indications
- Topical anesthesia of the oropharynx prior to intubation and other oropharyngeal procedures
Common side effects
- Transient numbness or tingling of oral mucosa
- Mild throat irritation
- Allergic reaction (rare)
- Systemic toxicity from excessive absorption (rare)
Key clinical trials
- Evaluation of the Effect of 10% Lidocaine Spray Undergoing Coronary Artery Bypass Graft Operation (PHASE4)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |