{"id":"orotracheal-lidocaine-oral-spray-application","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient numbness or tingling of oral mucosa"},{"rate":null,"effect":"Mild throat irritation"},{"rate":null,"effect":"Allergic reaction (rare)"},{"rate":null,"effect":"Systemic toxicity from excessive absorption (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lidocaine works by reversibly inhibiting sodium influx through voltage-gated sodium channels in the neuronal membrane, which stabilizes the membrane and raises the threshold for electrical excitability. When applied topically as an oral spray, it anesthetizes the oropharyngeal mucosa and surrounding tissues, providing rapid onset of local anesthesia. This effect is useful for reducing discomfort during intubation procedures and other oropharyngeal interventions.","oneSentence":"Lidocaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and conduction of nerve impulses to produce local anesthesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:58:59.779Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical anesthesia of the oropharynx prior to intubation and other oropharyngeal procedures"}]},"trialDetails":[{"nctId":"NCT03304431","phase":"PHASE4","title":"Evaluation of the Effect of 10% Lidocaine Spray Undergoing Coronary Artery Bypass Graft Operation","status":"COMPLETED","sponsor":"Abant Izzet Baysal University","startDate":"2017-05-26","conditions":"Cardiovascular Diseases, Lidocaine Causing Adverse Effects in Therapeutic Use, Tracheal Intubation Morbidity","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Orotracheal Lidocaine Oral Spray application","genericName":"Orotracheal Lidocaine Oral Spray application","companyName":"Abant Izzet Baysal University","companyId":"abant-izzet-baysal-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lidocaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and conduction of nerve impulses to produce local anesthesia. Used for Topical anesthesia of the oropharynx prior to intubation and other oropharyngeal procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}