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ORAL VORICONAZOLE and IV Amphotericin B
ORAL VORICONAZOLE and IV Amphotericin B is a Antifungal agents (triazole and polyene) Small molecule drug developed by All India Institute of Medical Sciences. It is currently in Phase 3 development for Invasive aspergillosis, Candidemia and other Candida infections, Cryptococcal meningitis.
Voriconazole and amphotericin B are antifungal agents that disrupt fungal cell membrane integrity, while voriconazole inhibits ergosterol synthesis and amphotericin B binds directly to ergosterol causing cell lysis.
Voriconazole and amphotericin B are antifungal agents that disrupt fungal cell membrane integrity, while voriconazole inhibits ergosterol synthesis and amphotericin B binds directly to ergosterol causing cell lysis. Used for Invasive aspergillosis, Candidemia and other Candida infections, Cryptococcal meningitis.
At a glance
| Generic name | ORAL VORICONAZOLE and IV Amphotericin B |
|---|---|
| Sponsor | All India Institute of Medical Sciences |
| Drug class | Antifungal agents (triazole and polyene) |
| Target | Fungal cytochrome P450 lanosterol 14α-demethylase (voriconazole); ergosterol (amphotericin B) |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Voriconazole is a triazole antifungal that inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, preventing ergosterol synthesis and destabilizing the fungal cell membrane. Amphotericin B is a polyene antibiotic that binds directly to ergosterol in the fungal cell membrane, creating pores that lead to cell leakage and death. The combination provides broad-spectrum antifungal coverage with complementary mechanisms of action.
Approved indications
- Invasive aspergillosis
- Candidemia and other Candida infections
- Cryptococcal meningitis
- Serious fungal infections in immunocompromised patients
Common side effects
- Visual disturbances
- Hepatotoxicity
- Nephrotoxicity (amphotericin B)
- Hypokalemia
- Infusion-related reactions
- Photosensitivity
- Rash
Key clinical trials
- Study of EL219 vs Standard of Care for Early Antifungal Therapy of Suspected Invasive Mould Infections (PHASE2)
- Antibiotic Impregnated Beads in Osteomyelitis (PHASE4)
- Antifungal Prophylaxis in Pediatric Acute Leukemia (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- ORAL VORICONAZOLE and IV Amphotericin B CI brief — competitive landscape report
- ORAL VORICONAZOLE and IV Amphotericin B updates RSS · CI watch RSS
- All India Institute of Medical Sciences portfolio CI
Frequently asked questions about ORAL VORICONAZOLE and IV Amphotericin B
What is ORAL VORICONAZOLE and IV Amphotericin B?
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Who makes ORAL VORICONAZOLE and IV Amphotericin B?
What drug class is ORAL VORICONAZOLE and IV Amphotericin B in?
What development phase is ORAL VORICONAZOLE and IV Amphotericin B in?
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What does ORAL VORICONAZOLE and IV Amphotericin B target?
Related
- Drug class: All Antifungal agents (triazole and polyene) drugs
- Target: All drugs targeting Fungal cytochrome P450 lanosterol 14α-demethylase (voriconazole); ergosterol (amphotericin B)
- Manufacturer: All India Institute of Medical Sciences — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Invasive aspergillosis
- Indication: Drugs for Candidemia and other Candida infections
- Indication: Drugs for Cryptococcal meningitis
- Compare: ORAL VORICONAZOLE and IV Amphotericin B vs similar drugs
- Pricing: ORAL VORICONAZOLE and IV Amphotericin B cost, discount & access