{"id":"oral-voriconazole-and-iv-amphotericin-b","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Visual disturbances"},{"rate":"10-15","effect":"Hepatotoxicity"},{"rate":"25-50","effect":"Nephrotoxicity (amphotericin B)"},{"rate":"15-25","effect":"Hypokalemia"},{"rate":"10-20","effect":"Infusion-related reactions"},{"rate":"5-10","effect":"Photosensitivity"},{"rate":"5-10","effect":"Rash"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Voriconazole is a triazole antifungal that inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, preventing ergosterol synthesis and destabilizing the fungal cell membrane. Amphotericin B is a polyene antibiotic that binds directly to ergosterol in the fungal cell membrane, creating pores that lead to cell leakage and death. The combination provides broad-spectrum antifungal coverage with complementary mechanisms of action.","oneSentence":"Voriconazole and amphotericin B are antifungal agents that disrupt fungal cell membrane integrity, while voriconazole inhibits ergosterol synthesis and amphotericin B binds directly to ergosterol causing cell lysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:24:52.179Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Invasive aspergillosis"},{"name":"Candidemia and other Candida infections"},{"name":"Cryptococcal meningitis"},{"name":"Serious fungal infections in immunocompromised patients"}]},"trialDetails":[{"nctId":"NCT07215273","phase":"PHASE2","title":"Study of EL219 vs Standard of Care for Early Antifungal Therapy of Suspected Invasive Mould Infections","status":"RECRUITING","sponsor":"Elion Therapeutics, Inc.","startDate":"2026-02","conditions":"Suspected Invasive Mould Infection","enrollment":80},{"nctId":"NCT07072923","phase":"PHASE4","title":"Antibiotic Impregnated Beads in Osteomyelitis","status":"NOT_YET_RECRUITING","sponsor":"University of Arizona","startDate":"2025-09-01","conditions":"Osteomyelitis of the Foot, Antibiotic Impregnated Beads, Osteomyelitis of Lower Extremities","enrollment":100},{"nctId":"NCT00624143","phase":"PHASE3","title":"Antifungal Prophylaxis in Pediatric Acute Leukemia","status":"UNKNOWN","sponsor":"All India Institute of Medical Sciences","startDate":"2008-02","conditions":"Pediatric Acute Leukemia Induction","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"ORAL VORICONAZOLE and IV Amphotericin B","genericName":"ORAL VORICONAZOLE and IV Amphotericin B","companyName":"All India Institute of Medical Sciences","companyId":"all-india-institute-of-medical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Voriconazole and amphotericin B are antifungal agents that disrupt fungal cell membrane integrity, while voriconazole inhibits ergosterol synthesis and amphotericin B binds directly to ergosterol causing cell lysis. Used for Invasive aspergillosis, Candidemia and other Candida infections, Cryptococcal meningitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}