Last reviewed · How we verify
Oral Rehydration Therapy
Oral Rehydration Therapy (ORT) replaces lost fluids and electrolytes (sodium, potassium, chloride, glucose) through the small intestine to restore hydration and electrolyte balance.
Oral Rehydration Therapy (ORT) replaces lost fluids and electrolytes (sodium, potassium, chloride, glucose) through the small intestine to restore hydration and electrolyte balance. Used for Acute diarrhea and dehydration, Cholera, Gastroenteritis.
At a glance
| Generic name | Oral Rehydration Therapy |
|---|---|
| Also known as | Enterolyte |
| Sponsor | Sanofi |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology / Emergency Medicine |
| Phase | FDA-approved |
Mechanism of action
ORT is a non-pharmacological intervention consisting of a glucose-electrolyte solution designed to be absorbed efficiently by the small intestine. The sodium-glucose cotransporter mechanism enhances water absorption, making it effective for rehydration in dehydration states. It addresses fluid and electrolyte losses without requiring intravenous administration.
Approved indications
- Acute diarrhea and dehydration
- Cholera
- Gastroenteritis
- Dehydration from vomiting or other causes
Common side effects
- Hypernatremia (if improperly formulated)
- Hyperglycemia (in diabetic patients)
- Nausea
Key clinical trials
- Rifaximin 200 mg Plus Oral Rehydration vs Oral Rehydration Alone in Children With Acute Diarrhea (PHASE4)
- Fortified Oral Rehydration Therapy for Pediatric Diarrhea (PHASE1, PHASE2)
- Safety and Efficacy of Racecadotril in Children With Acute Watery Diarrhea (NA)
- Lactobacillus Acidophilus and Limosilactobacillus Reuteri for Acute Diarrhea in Children (NA)
- Evaluation of the Role of Vitamin D in Reducing the Severity and Duration of Rotavirus Infection in Iraqi Children (NA)
- Preventative Intervention for Cholera for 7 Days (NA)
- Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7) Water, Sanitation, and Hygiene (WASH) Case Area Targeted Intervention (CATI) (NA)
- Next Generation ORS: Controlled Trial Comparing ORS With Calcium vs Standard ORS in Reducing Severity of Acute Watery Diarrhea (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Oral Rehydration Therapy CI brief — competitive landscape report
- Oral Rehydration Therapy updates RSS · CI watch RSS
- Sanofi portfolio CI