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Oral Anticoagulant, Direct-Acting
Oral Anticoagulant, Direct-Acting is a Direct-acting oral anticoagulant (DOAC) Small molecule drug developed by Assistance Publique - Hôpitaux de Paris. It is currently in Phase 3 development for Atrial fibrillation for stroke prevention, Venous thromboembolism prevention and treatment. Also known as: HMG-CoA reductase inhibitors, platelet aggregation inhibitors from the P2Y12 receptor antagonist group.
Direct-acting oral anticoagulants inhibit specific clotting factors (typically Factor Xa or thrombin) to prevent blood clot formation.
Direct-acting oral anticoagulants inhibit specific clotting factors (typically Factor Xa or thrombin) to prevent blood clot formation. Used for Atrial fibrillation for stroke prevention, Venous thromboembolism prevention and treatment.
At a glance
| Generic name | Oral Anticoagulant, Direct-Acting |
|---|---|
| Also known as | HMG-CoA reductase inhibitors, platelet aggregation inhibitors from the P2Y12 receptor antagonist group |
| Sponsor | Assistance Publique - Hôpitaux de Paris |
| Drug class | Direct-acting oral anticoagulant (DOAC) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
Direct-acting oral anticoagulants (DOACs) work by selectively inhibiting key enzymes in the coagulation cascade without requiring monitoring or cofactors like vitamin K. They provide rapid onset of anticoagulant effect and predictable pharmacokinetics, making them suitable for oral administration in conditions requiring thromboembolism prevention.
Approved indications
- Atrial fibrillation for stroke prevention
- Venous thromboembolism prevention and treatment
Common side effects
- Bleeding (major and minor)
- Gastrointestinal bleeding
- Dyspepsia
Key clinical trials
- PFO Closure, Oral Anticoagulants or Antiplatelet Therapy After PFO-associated Stroke in Patients Aged 60 to 80 Years (PHASE3)
- Treatment of Cardiovascular Disease With Low Dose Rivaroxaban in Advanced Chronic Kidney Disease (PHASE3)
- The Danish Non-vitamin K Antagonist Oral Anticoagulation Study in Patients With Atrial Fibrillation (PHASE4)
- The Danish Non-vitamin K Antagonist Oral Anticoagulation Study in Patients With Venous Thromboembolism (DANNOAC-VTE) (PHASE4)
- Effects of Edoxaban on Platelet Aggregation (PHASE2, PHASE3)
- Timing to Restart Direct Oral Anticoagulants After Traumatic Intracranial Haemorrhage (PHASE3)
- Monotherapy With P2Y12 Inhibitors in Patients With Atrial fIbrillation Undergoing Supraflex Stent Implantation (PHASE4)
- Assessment of a Procedure for Managing Oral Anticoagulants (NACO) in the Management of Fractures
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Oral Anticoagulant, Direct-Acting CI brief — competitive landscape report
- Oral Anticoagulant, Direct-Acting updates RSS · CI watch RSS
- Assistance Publique - Hôpitaux de Paris portfolio CI
Frequently asked questions about Oral Anticoagulant, Direct-Acting
What is Oral Anticoagulant, Direct-Acting?
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Related
- Drug class: All Direct-acting oral anticoagulant (DOAC) drugs
- Manufacturer: Assistance Publique - Hôpitaux de Paris — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Atrial fibrillation for stroke prevention
- Indication: Drugs for Venous thromboembolism prevention and treatment
- Also known as: HMG-CoA reductase inhibitors, platelet aggregation inhibitors from the P2Y12 receptor antagonist group
- Compare: Oral Anticoagulant, Direct-Acting vs similar drugs
- Pricing: Oral Anticoagulant, Direct-Acting cost, discount & access