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Opioid-Free Postoperative Pain Regimen
A multimodal postoperative pain management protocol that combines non-opioid analgesics, regional anesthesia, and non-pharmacological interventions to provide effective pain control without opioid medications.
A multimodal postoperative pain management protocol that combines non-opioid analgesics, regional anesthesia, and non-pharmacological interventions to provide effective pain control without opioid medications. Used for Postoperative pain management across surgical specialties.
At a glance
| Generic name | Opioid-Free Postoperative Pain Regimen |
|---|---|
| Sponsor | Vanderbilt University Medical Center |
| Drug class | Multimodal analgesic regimen |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Perioperative Medicine |
| Phase | FDA-approved |
Mechanism of action
This regimen integrates acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), local anesthetics, nerve blocks, and adjunctive agents such as gabapentinoids or ketamine to address pain through multiple mechanisms while avoiding opioid-related adverse effects. The approach leverages synergistic effects of different drug classes and techniques to achieve adequate analgesia while reducing postoperative complications associated with opioid use, including respiratory depression, constipation, and opioid-induced hyperalgesia.
Approved indications
- Postoperative pain management in surgical patients
Common side effects
- Gastrointestinal upset (NSAIDs)
- Hepatotoxicity risk (acetaminophen overdose)
- Local anesthetic toxicity (regional blocks)
- Dizziness or sedation (adjunctive agents)
Key clinical trials
- Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
- Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy (PHASE2, PHASE3)
- Opioid-Free Pain Management After NUSS Surgery in Adolescents
- Prospective Opioid-Free AIS Fusion (PHASE4)
- Postoperative Analgesia Intervention With Non-opioid Alternatives (PAIN-Alt) Trial - Breast Surgery (NA)
- Pilot Trial: Postoperative Opioid-free Analgesia (PHASE2, PHASE3)
- Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery (PHASE4)
- Opioid-free Analgesia for the Management of Acute Post-operative Pain Following Caesarean Section (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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