{"id":"opioid-free-postoperative-pain-regimen","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset (NSAIDs)"},{"rate":null,"effect":"Hepatotoxicity risk (acetaminophen overdose)"},{"rate":null,"effect":"Local anesthetic toxicity (regional blocks)"},{"rate":null,"effect":"Dizziness or sedation (adjunctive agents)"}]},"_chembl":{"chemblId":"CHEMBL5082715","moleculeType":"Unknown","molecularWeight":"398.50"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This regimen integrates acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), local anesthetics, nerve blocks, and adjunctive agents such as gabapentinoids or ketamine to address pain through multiple mechanisms while avoiding opioid-related adverse effects. The approach leverages synergistic effects of different drug classes and techniques to achieve adequate analgesia while reducing postoperative complications associated with opioid use, including respiratory depression, constipation, and opioid-induced hyperalgesia.","oneSentence":"A multimodal postoperative pain management protocol that combines non-opioid analgesics, regional anesthesia, and non-pharmacological interventions to provide effective pain control without opioid medications.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:58:28.281Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain management in surgical patients"}]},"trialDetails":[{"nctId":"NCT07489001","phase":"","title":"Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery","status":"RECRUITING","sponsor":"Marmara University","startDate":"2025-12-09","conditions":"Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative Spondylolisthesis","enrollment":75},{"nctId":"NCT05597878","phase":"PHASE2, PHASE3","title":"Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy","status":"SUSPENDED","sponsor":"Wake Forest University Health Sciences","startDate":"2023-04-18","conditions":"Pain Management, Opioid Use, Prostate Cancer","enrollment":100},{"nctId":"NCT07288424","phase":"","title":"Opioid-Free Pain Management After NUSS Surgery in Adolescents","status":"COMPLETED","sponsor":"Qin Zhang","startDate":"2025-06-01","conditions":"Nerve Block","enrollment":17},{"nctId":"NCT06935331","phase":"PHASE4","title":"Prospective Opioid-Free AIS Fusion","status":"NOT_YET_RECRUITING","sponsor":"OrthoCarolina Research Institute, Inc.","startDate":"2025-08-15","conditions":"Adolescent Idiopathic Scoliosis (AIS)","enrollment":58},{"nctId":"NCT06507345","phase":"NA","title":"Postoperative Analgesia Intervention With Non-opioid Alternatives (PAIN-Alt) Trial - Breast Surgery","status":"RECRUITING","sponsor":"McGill University Health Centre/Research Institute of the McGill University Health Centre","startDate":"2024-11-26","conditions":"Post Operative Pain, Opioid Analgesic Adverse Reaction, Surgery","enrollment":540},{"nctId":"NCT04254679","phase":"PHASE2, PHASE3","title":"Pilot Trial: Postoperative Opioid-free Analgesia","status":"COMPLETED","sponsor":"McGill University Health Centre/Research Institute of the McGill University Health Centre","startDate":"2020-01-29","conditions":"Outpatient Surgery, Abdominal Surgery, Breast Surgery","enrollment":81},{"nctId":"NCT04990804","phase":"PHASE4","title":"Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery","status":"TERMINATED","sponsor":"Vanderbilt University Medical Center","startDate":"2021-08-01","conditions":"Opioid Use, Spinal Diseases, Surgery--Complications","enrollment":8},{"nctId":"NCT04539249","phase":"NA","title":"Opioid-free Analgesia for the Management of Acute Post-operative Pain Following Caesarean Section","status":"COMPLETED","sponsor":"Olakunle Ifeoluwa Makinde","startDate":"2020-11-04","conditions":"Acute Post-operative Pain Following Caesarean Section","enrollment":324},{"nctId":"NCT04766996","phase":"PHASE4","title":"PROUD Study - Preventing Opioid Use Disorders","status":"TERMINATED","sponsor":"Emory University","startDate":"2021-05-17","conditions":"Anesthesia, Opioid Use","enrollment":57}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Opioid-Free Postoperative Pain Regimen","genericName":"Opioid-Free Postoperative Pain Regimen","companyName":"Vanderbilt University Medical Center","companyId":"vanderbilt-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A multimodal postoperative pain management protocol that combines non-opioid analgesics, regional anesthesia, and non-pharmacological interventions to provide effective pain control without opioid medications. Used for Postoperative pain management across surgical specialties.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}