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Opioid-Free/Opioid-Avoidant
Opioid-free/opioid-avoidant pain management represents a therapeutic approach that uses non-opioid analgesics and multimodal pain control strategies to treat pain while avoiding opioid dependence and associated risks.
Opioid-free/opioid-avoidant pain management represents a therapeutic approach that uses non-opioid analgesics and multimodal pain control strategies to treat pain while avoiding opioid dependence and associated risks. Used for Perioperative pain management in orthopedic surgery, Acute postoperative pain without opioid use.
At a glance
| Generic name | Opioid-Free/Opioid-Avoidant |
|---|---|
| Sponsor | OrthoCarolina Research Institute, Inc. |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Orthopedic Surgery |
| Phase | FDA-approved |
Mechanism of action
This is a clinical strategy rather than a single drug entity, combining non-opioid medications (such as NSAIDs, acetaminophen, local anesthetics, and adjuvant agents), regional anesthesia, and physical/behavioral interventions to manage acute and chronic pain. The approach aims to reduce opioid exposure, minimize addiction risk, and improve patient outcomes by addressing pain through multiple mechanisms simultaneously.
Approved indications
- Acute postoperative pain management
- Chronic pain conditions (alternative to opioid therapy)
Common side effects
Key clinical trials
- Prospective Opioid-Free AIS Fusion (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |