{"id":"opioid-free-opioid-avoidant","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a clinical strategy rather than a single drug entity, combining non-opioid medications (such as NSAIDs, acetaminophen, local anesthetics, and adjuvant agents), regional anesthesia, and physical/behavioral interventions to manage acute and chronic pain. The approach aims to reduce opioid exposure, minimize addiction risk, and improve patient outcomes by addressing pain through multiple mechanisms simultaneously.","oneSentence":"Opioid-free/opioid-avoidant pain management represents a therapeutic approach that uses non-opioid analgesics and multimodal pain control strategies to treat pain while avoiding opioid dependence and associated risks.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:35:22.667Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute postoperative pain management"},{"name":"Chronic pain conditions (alternative to opioid therapy)"}]},"trialDetails":[{"nctId":"NCT06935331","phase":"PHASE4","title":"Prospective Opioid-Free AIS Fusion","status":"NOT_YET_RECRUITING","sponsor":"OrthoCarolina Research Institute, Inc.","startDate":"2025-08-15","conditions":"Adolescent Idiopathic Scoliosis (AIS)","enrollment":58}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Opioid-Free/Opioid-Avoidant","genericName":"Opioid-Free/Opioid-Avoidant","companyName":"OrthoCarolina Research Institute, Inc.","companyId":"orthocarolina-research-institute-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Opioid-free/opioid-avoidant pain management represents a therapeutic approach that uses non-opioid analgesics and multimodal pain control strategies to treat pain while avoiding opioid dependence and associated risks. Used for Perioperative pain management in orthopedic surgery, Acute postoperative pain without opioid use.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}