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Onion extract gel
Onion extract gel is a Botanical topical agent Small molecule drug developed by University of Miami. It is currently FDA-approved for Scar appearance reduction (hypertrophic and keloid scars), Wound healing support. Also known as: Mederma.
Onion extract gel promotes wound healing and scar reduction through anti-inflammatory and antimicrobial properties of sulfur-containing compounds.
Onion extract gel promotes wound healing and scar reduction through anti-inflammatory and antimicrobial properties of sulfur-containing compounds. Used for Scar appearance reduction (hypertrophic and keloid scars), Wound healing support.
At a glance
| Generic name | Onion extract gel |
|---|---|
| Also known as | Mederma |
| Sponsor | University of Miami |
| Drug class | Botanical topical agent |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Onion extract contains quercetin and other polyphenols that reduce inflammation and collagen deposition in healing wounds. The gel formulation allows topical delivery to affected skin, potentially inhibiting excessive fibroblast proliferation and promoting more organized collagen remodeling to minimize scar formation.
Approved indications
- Scar appearance reduction (hypertrophic and keloid scars)
- Wound healing support
Common side effects
- Local skin irritation
- Allergic contact dermatitis
- Odor
Key clinical trials
- Effect of Onion Extract Nanoparticle Gel Phonophoresis on Postsurgical Scar of Cesarean Section. (NA)
- "A Clinical Study Investigating the Effectiveness of OTC Scar-management Modalities" (NA)
- Efficacy and Safety of Silicone Cream Containing Allium Cepa Extract (NA)
- Silicone Gel Versus Onion Extract Gel as Prevention for Postsurgical Scars (PHASE3)
- A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars (PHASE4)
- The Efficacy of Extract of Allium Cepae, Allantoin and Heparin in Patients With Proven Scar Development (NA)
- Contractubex Treatment in Scars After Abdominal Caesarean Section (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Onion extract gel CI brief — competitive landscape report
- Onion extract gel updates RSS · CI watch RSS
- University of Miami portfolio CI
Frequently asked questions about Onion extract gel
What is Onion extract gel?
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Related
- Drug class: All Botanical topical agent drugs
- Manufacturer: University of Miami — full pipeline
- Therapeutic area: All drugs in Dermatology
- Indication: Drugs for Scar appearance reduction (hypertrophic and keloid scars)
- Indication: Drugs for Wound healing support
- Also known as: Mederma
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing