{"id":"onion-extract-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Odor"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Onion extract contains quercetin and other polyphenols that reduce inflammation and collagen deposition in healing wounds. The gel formulation allows topical delivery to affected skin, potentially inhibiting excessive fibroblast proliferation and promoting more organized collagen remodeling to minimize scar formation.","oneSentence":"Onion extract gel promotes wound healing and scar reduction through anti-inflammatory and antimicrobial properties of sulfur-containing compounds.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:41:56.979Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Scar appearance reduction (hypertrophic and keloid scars)"},{"name":"Wound healing support"}]},"trialDetails":[{"nctId":"NCT06658444","phase":"NA","title":"Effect of Onion Extract Nanoparticle Gel Phonophoresis on Postsurgical Scar of Cesarean Section.","status":"RECRUITING","sponsor":"October 6 University","startDate":"2024-09-12","conditions":"Scar; Previous Cesarean Section","enrollment":40},{"nctId":"NCT04169490","phase":"NA","title":"\"A Clinical Study Investigating the Effectiveness of OTC Scar-management Modalities\"","status":"COMPLETED","sponsor":"The Center for Clinical and Cosmetic Research","startDate":"2019-02-07","conditions":"Scar, Keloid, Hypertrophic Scar","enrollment":75},{"nctId":"NCT04233320","phase":"NA","title":"Efficacy and Safety of Silicone Cream Containing Allium Cepa Extract","status":"UNKNOWN","sponsor":"Chulalongkorn University","startDate":"2020-02-01","conditions":"Cicatrix","enrollment":22},{"nctId":"NCT01861119","phase":"PHASE3","title":"Silicone Gel Versus Onion Extract Gel as Prevention for Postsurgical Scars","status":"COMPLETED","sponsor":"CHA University","startDate":"2013-04-01","conditions":"Hypertrophic or Keloid Scars","enrollment":90},{"nctId":"NCT00754247","phase":"PHASE4","title":"A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars","status":"COMPLETED","sponsor":"University of Miami","startDate":"2006-03","conditions":"Keloid, Hypertrophic Scar, Cicatrix, Hypertrophic","enrollment":30},{"nctId":"NCT02708628","phase":"NA","title":"The Efficacy of Extract of Allium Cepae, Allantoin and Heparin in Patients With Proven Scar Development","status":"COMPLETED","sponsor":"Suleymaniye Birth And Women's Health Education And Research Hospital","startDate":"2015-12","conditions":"Cicatrix","enrollment":120},{"nctId":"NCT01112371","phase":"PHASE4","title":"Contractubex Treatment in Scars After Abdominal Caesarean Section","status":"COMPLETED","sponsor":"Merz Pharmaceuticals GmbH","startDate":"2011-02","conditions":"Scars","enrollment":61}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":14,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Mederma"],"phase":"marketed","status":"active","brandName":"Onion extract gel","genericName":"Onion extract gel","companyName":"University of Miami","companyId":"university-of-miami","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Onion extract gel promotes wound healing and scar reduction through anti-inflammatory and antimicrobial properties of sulfur-containing compounds. Used for Scar appearance reduction (hypertrophic and keloid scars), Wound healing support.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}