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OnabotulinumtoxinA Injectable Product
OnabotulinumtoxinA Injectable Product is a Botulinum toxin Small molecule drug developed by University of Utah. It is currently FDA-approved for Cervical dystonia, Blepharospasm, Strabismus. Also known as: Botox.
OnabotulinumtoxinA blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.
OnabotulinumtoxinA blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis. Used for Cervical dystonia, Blepharospasm, Strabismus.
At a glance
| Generic name | OnabotulinumtoxinA Injectable Product |
|---|---|
| Also known as | Botox |
| Sponsor | University of Utah |
| Drug class | Botulinum toxin |
| Target | SNAP-25 (synaptosomal-associated protein 25) |
| Modality | Small molecule |
| Therapeutic area | Neurology, Dermatology, Ophthalmology |
| Phase | FDA-approved |
Mechanism of action
The drug is a botulinum toxin serotype A that irreversibly cleaves SNAP-25, a protein essential for acetylcholine vesicle fusion and release. This prevents neuromuscular transmission, resulting in localized muscle weakness or paralysis that typically lasts 3-4 months. The effect is reversible as the body gradually regenerates new nerve terminals.
Approved indications
- Cervical dystonia
- Blepharospasm
- Strabismus
- Chronic migraine
- Severe primary axillary hyperhidrosis
- Upper limb spasticity
- Urinary incontinence due to neurogenic detrusor overactivity
Common side effects
- Headache
- Neck pain
- Injection site pain
- Muscle weakness
- Eyelid ptosis
- Dry mouth
- Flu-like symptoms
Key clinical trials
- A Study to Evaluate Patient Satisfaction With the Overall Face and Neck Appearance After Combined Treatment of OnabotulinumtoxinA, JUVÉDERM® Products, KYBELLA, CoolSculpting Elite and SkinMedica Products (PHASE4)
- A Study on Recombinant Botulinum Toxin Type A (YY001) for Injection in Multiple Treatments of Adult Upper Limb Spasticity (PHASE3)
- A Real-World Study on Effect of Hirudoid on Ecchymosis After Treatment of Crow's Feet With Botulinum Toxin Type A (PHASE4)
- Botulinum Toxin Versus Platelet Rich Fibrin for TMJ Internal Derangement (NA)
- A Phase 3 Clinical Study to Evaluate the Efficacy and Safety of Botulinum Toxin Type A for Injection (CU-20101) (PHASE3)
- Exercise to Improve Sleep and Quality of Life in Stroke Patients Receiving Botulinum Toxin Treatment (NA)
- Treatment of Hypertrophic Scars Using Fractional CO2 Laser Alone in Comparison With Adding Botulinum Toxin Either Through Intralesional Injection or Assisted Drug Delivery (NA)
- OnabotulinumtoxinA for Trigeminal Neuralgia (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- OnabotulinumtoxinA Injectable Product CI brief — competitive landscape report
- OnabotulinumtoxinA Injectable Product updates RSS · CI watch RSS
- University of Utah portfolio CI
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Related
- Drug class: All Botulinum toxin drugs
- Target: All drugs targeting SNAP-25 (synaptosomal-associated protein 25)
- Manufacturer: University of Utah — full pipeline
- Therapeutic area: All drugs in Neurology, Dermatology, Ophthalmology
- Indication: Drugs for Cervical dystonia
- Indication: Drugs for Blepharospasm
- Indication: Drugs for Strabismus
- Also known as: Botox
- Compare: OnabotulinumtoxinA Injectable Product vs similar drugs
- Pricing: OnabotulinumtoxinA Injectable Product cost, discount & access