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Onabotulinumtoxina for Injection
Onabotulinumtoxina for Injection is a Botulinum toxin Small molecule drug developed by University of Pennsylvania. It is currently FDA-approved for Cervical dystonia, Blepharospasm, Strabismus. Also known as: Botox.
Onabotulinumtoxina blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.
Onabotulinumtoxina blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis. Used for Cervical dystonia, Blepharospasm, Strabismus.
At a glance
| Generic name | Onabotulinumtoxina for Injection |
|---|---|
| Also known as | Botox |
| Sponsor | University of Pennsylvania |
| Drug class | Botulinum toxin |
| Target | SNAP-25 (synaptosome-associated protein of 25 kDa) |
| Modality | Small molecule |
| Therapeutic area | Neurology, Dermatology, Urology |
| Phase | FDA-approved |
Mechanism of action
The drug is a botulinum toxin serotype A that irreversibly cleaves SNAP-25, a protein essential for acetylcholine vesicle release. This results in denervation of muscle fibers and temporary paralysis lasting 3-4 months. It is used therapeutically to reduce muscle contractions in various conditions including dystonia, spasticity, and cosmetic applications.
Approved indications
- Cervical dystonia
- Blepharospasm
- Strabismus
- Chronic migraine
- Spasticity
- Hyperhidrosis
- Urinary incontinence due to neurogenic detrusor overactivity
- Cosmetic use (glabellar lines, forehead lines, crow's feet)
Common side effects
- Headache
- Neck pain
- Injection site pain
- Muscle weakness
- Eyelid ptosis
- Diplopia
- Dry mouth
- Flu-like symptoms
Key clinical trials
- DaxibotulinumtoxinA Injection for Treatment of Adductor Spasmodic Dysphonia (PHASE1, PHASE2)
- Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic Neuropathic Pain in Post-mastectomy Syndrome (PHASE2)
- DaxibotulinumtoxinA for Blepharospasm (PHASE2)
- A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine (PHASE3)
- A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine (PHASE3)
- Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury (PHASE3)
- Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing With Shoulder Pain and Functional Problems Caused by Spasticity and Motor Impairment (NA)
- A Study on Recombinant Botulinum Toxin Type A (YY001) for Injection in Multiple Treatments of Adult Upper Limb Spasticity (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Onabotulinumtoxina for Injection CI brief — competitive landscape report
- Onabotulinumtoxina for Injection updates RSS · CI watch RSS
- University of Pennsylvania portfolio CI
Frequently asked questions about Onabotulinumtoxina for Injection
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Related
- Drug class: All Botulinum toxin drugs
- Target: All drugs targeting SNAP-25 (synaptosome-associated protein of 25 kDa)
- Manufacturer: University of Pennsylvania — full pipeline
- Therapeutic area: All drugs in Neurology, Dermatology, Urology
- Indication: Drugs for Cervical dystonia
- Indication: Drugs for Blepharospasm
- Indication: Drugs for Strabismus
- Also known as: Botox
- Compare: Onabotulinumtoxina for Injection vs similar drugs
- Pricing: Onabotulinumtoxina for Injection cost, discount & access