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OnabotulinumtoxinA 100 UNT
OnabotulinumtoxinA 100 UNT is a Botulinum toxin Small molecule drug developed by University of South Florida. It is currently FDA-approved for Cervical dystonia, Blepharospasm, Strabismus. Also known as: BOTOX.
OnabotulinumtoxinA blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.
OnabotulinumtoxinA blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis. Used for Cervical dystonia, Blepharospasm, Strabismus.
At a glance
| Generic name | OnabotulinumtoxinA 100 UNT |
|---|---|
| Also known as | BOTOX |
| Sponsor | University of South Florida |
| Drug class | Botulinum toxin |
| Target | SNAP-25 (synaptosome-associated protein of 25 kDa) |
| Modality | Small molecule |
| Therapeutic area | Neurology; Dermatology; Aesthetics |
| Phase | FDA-approved |
Mechanism of action
OnabotulinumtoxinA is a botulinum toxin serotype A that irreversibly cleaves SNAP-25, a protein essential for acetylcholine vesicle fusion and release. This prevents neuromuscular transmission, resulting in temporary paralysis of injected muscles. The effect is localized to the injection site and gradually reverses over 3-4 months as new neuromuscular junctions form.
Approved indications
- Cervical dystonia
- Blepharospasm
- Strabismus
- Chronic migraine
- Overactive bladder
- Spasticity
- Glabellar lines (aesthetic use)
Common side effects
- Headache
- Neck pain
- Injection site pain
- Muscle weakness
- Dysphagia
- Ptosis
- Flu-like symptoms
Key clinical trials
- Intradetrusor Botulinum Toxin A for OAB Via 1 Versus 10 Injections: A Randomized Clinical Trial (PHASE4)
- OnabotulinumtoxinA for Trigeminal Neuralgia (PHASE4)
- Beta-Agonist Versus OnabotulinumtoxinA Trial for Urgency Urinary Incontinence (PHASE4)
- Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis (PHASE2)
- Botulinum Toxin a Vs Anticholinergic Treatment of Neurogenic Overactive Bladder in Patients with Multiple Sclerosis (PHASE4)
- Evaluation of Intradetrusor AbobotulinumtoxinA and IncobotulinumtoxinA in Women With Overactive Bladder (PHASE4)
- Xeomin vs Botox for Treatment of Overactive Bladder Syndrome (PHASE2)
- INcobotulinumtoxina in ChIldren Upper and Lower Limb sPasticITy (INCIPIT) (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- OnabotulinumtoxinA 100 UNT CI brief — competitive landscape report
- OnabotulinumtoxinA 100 UNT updates RSS · CI watch RSS
- University of South Florida portfolio CI
Frequently asked questions about OnabotulinumtoxinA 100 UNT
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Related
- Drug class: All Botulinum toxin drugs
- Target: All drugs targeting SNAP-25 (synaptosome-associated protein of 25 kDa)
- Manufacturer: University of South Florida — full pipeline
- Therapeutic area: All drugs in Neurology; Dermatology; Aesthetics
- Indication: Drugs for Cervical dystonia
- Indication: Drugs for Blepharospasm
- Indication: Drugs for Strabismus
- Also known as: BOTOX