Last reviewed · How we verify
Nux vomica (active comparator)
Nux vomica contains strychnine and other alkaloids that act as competitive antagonists at glycine receptors in the spinal cord and brainstem, increasing neuronal excitability and motor reflex activity.
Nux vomica contains strychnine and other alkaloids that act as competitive antagonists at glycine receptors in the spinal cord and brainstem, increasing neuronal excitability and motor activity. Used for Constipation and digestive complaints (historical/traditional use), Bitter tonic for appetite stimulation (historical use).
At a glance
| Generic name | Nux vomica (active comparator) |
|---|---|
| Also known as | Strychnos Nux vomica C200 |
| Sponsor | Medical University of Vienna |
| Drug class | Herbal alkaloid preparation |
| Target | Glycine receptor (competitive antagonist) |
| Modality | Small molecule |
| Therapeutic area | Gastrointestinal / Traditional Medicine |
| Phase | FDA-approved |
Mechanism of action
Strychnine, the primary active alkaloid in Nux vomica, blocks inhibitory glycine receptors, removing the normal suppression of motor neurons. This leads to increased muscle tone and reflex responses. Historically used in traditional and homeopathic medicine as a general tonic and stimulant, though its narrow therapeutic window and toxicity profile limit modern clinical use.
Approved indications
- General tonic and stimulant (traditional use)
- Digestive complaints (traditional use)
Common side effects
- Muscle rigidity and spasticity
- Tremor
- Convulsions (at higher doses)
- Respiratory depression
Key clinical trials
- Homeopathy for Prevention of Atrial Fibrillation After Aortocoronary Bypass Surgery (PHASE4)
- Monthly Itraconazole Versus Classic Homeopathy for Treatment of Recurrent Vulvovaginal Candidiasis (RVVC) (NA)
- Homeopathic Treatment of Premenstrual Syndrome (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Nux vomica (active comparator) CI brief — competitive landscape report
- Nux vomica (active comparator) updates RSS · CI watch RSS
- Medical University of Vienna portfolio CI