{"id":"nux-vomica-active-comparator","safety":{"commonSideEffects":[{"rate":null,"effect":"Muscle rigidity and spasticity"},{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Convulsions (at higher doses)"},{"rate":null,"effect":"Respiratory depression"}]},"_chembl":{"chemblId":"CHEMBL2107927","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Strychnine, the primary active alkaloid in Nux vomica, blocks inhibitory glycine receptors, removing the normal suppression of motor neurons. This leads to increased muscle tone and reflex responses. Historically used in traditional and homeopathic medicine as a general tonic and stimulant, though its narrow therapeutic window and toxicity profile limit modern clinical use.","oneSentence":"Nux vomica contains strychnine and other alkaloids that act as competitive antagonists at glycine receptors in the spinal cord and brainstem, increasing neuronal excitability and motor reflex activity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:41:19.512Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"General tonic and stimulant (traditional use)"},{"name":"Digestive complaints (traditional use)"}]},"trialDetails":[{"nctId":"NCT00861237","phase":"PHASE4","title":"Homeopathy for Prevention of Atrial Fibrillation After Aortocoronary Bypass Surgery","status":"TERMINATED","sponsor":"Medical University of Vienna","startDate":"2008-07","conditions":"Atrial Fibrillation","enrollment":12},{"nctId":"NCT00895453","phase":"NA","title":"Monthly Itraconazole Versus Classic Homeopathy for Treatment of Recurrent Vulvovaginal Candidiasis (RVVC)","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2000-05","conditions":"Vulvovaginal Candidiasis","enrollment":144},{"nctId":"NCT02402049","phase":"PHASE3","title":"Homeopathic Treatment of Premenstrual Syndrome","status":"UNKNOWN","sponsor":"Shaare Zedek Medical Center","startDate":"2015-03","conditions":"Premenstrual Syndrome-PMS","enrollment":180}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Strychnos Nux vomica C200"],"phase":"marketed","status":"active","brandName":"Nux vomica (active comparator)","genericName":"Nux vomica (active comparator)","companyName":"Medical University of Vienna","companyId":"medical-university-of-vienna","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nux vomica contains strychnine and other alkaloids that act as competitive antagonists at glycine receptors in the spinal cord and brainstem, increasing neuronal excitability and motor activity. Used for Constipation and digestive complaints (historical/traditional use), Bitter tonic for appetite stimulation (historical use).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}