Last reviewed 2026-05-21 · How we verify

Normal Saline intrathecally

Normal Saline intrathecally is a Electrolyte solution / Physiologic fluid Small molecule drug developed by KAT General Hospital. It is currently FDA-approved for Intrathecal administration as a vehicle or diluent for other medications, Diagnostic imaging procedures requiring CSF replacement, Management of certain spinal cord conditions. Also known as: N/S.

Normal saline administered intrathecally provides cerebrospinal fluid (CSF) replacement and maintains osmotic balance within the spinal canal and brain.

Normal Saline is used intrathecally in clinical trials for conditions such as epidural analgesia, obstetric pain, postoperative pain, analgesia, and colorectal cancer. The mechanism of action of Normal Saline is unknown, as per ChEMBL.

At a glance

Mechanism of action

Normal saline (0.9% sodium chloride) is an isotonic solution that, when injected into the intrathecal space, serves as a physiologic fluid to replace or supplement CSF. It helps maintain proper osmotic pressure and ionic balance in the central nervous system, and may be used for diagnostic purposes (e.g., as a vehicle for contrast agents) or therapeutic purposes (e.g., dilution of other intrathecal medications or management of certain spinal conditions).

Approved indications

• Intrathecal administration as a vehicle or diluent for other medications
• Diagnostic imaging procedures requiring CSF replacement
• Management of certain spinal cord conditions

Common side effects

• Headache (post-dural puncture)
• Back pain
• Infection (meningitis)
• Neurological complications from injection trauma

Key clinical trials

• PENG vs L-ESPB With S-ESPB for Analgesia in Total Hip Arthroplasty (PHASE4)
• A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK (PHASE1)
• A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV) (PHASE1)
• Intrathecal Non-preservative-free Morphine With Bupivacaine Versus Intrathecal Bupivacaine Alone for Analgesia in Unilateral Inguinal Hernia Repair Surgeries (PHASE3)
• Efficacy of Perioperative Opioid Sparing Techniques on Time to Initiation of Chemotherapy (NA)
• Comparative Analysis of Analgesic Efficacy: by Single Shot Intrathecal Analgesia (SSSA) in Normal Labor (PHASE4)
• Intrathecal Administration of Autologous Mesenchymal Stem Cell-derived Neural Progenitors (MSC-NP) in Progressive Multiple Sclerosis (PHASE2)
• Intrathecal Fentanyl and Dexmedetomidine Added to Bupivacaine for Subarachnoid Anaesthesia for Percutaneous Nephrolithotomy (NA)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Normal Saline intrathecally CI brief — competitive landscape report
• Normal Saline intrathecally updates RSS · CI watch RSS
• KAT General Hospital portfolio CI

Frequently asked questions about Normal Saline intrathecally

Related

• Drug class: All Electrolyte solution / Physiologic fluid drugs
• Manufacturer: KAT General Hospital — full pipeline
• Therapeutic area: All drugs in Neurology / Supportive Care
• Indication: Drugs for Intrathecal administration as a vehicle or diluent for other medications
• Indication: Drugs for Diagnostic imaging procedures requiring CSF replacement
• Indication: Drugs for Management of certain spinal cord conditions
• Also known as: N/S

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing