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Norepinephrine (static group)
Norepinephrine is a catecholamine that binds to alpha and beta adrenergic receptors to increase heart rate, blood pressure, and cardiac contractility.
Norepinephrine is a catecholamine that binds to alpha and beta adrenergic receptors to increase heart rate, blood pressure, and cardiac contractility. Used for Acute hypotension and shock (septic, cardiogenic, hypovolemic), Maintenance of blood pressure during anesthesia.
At a glance
| Generic name | Norepinephrine (static group) |
|---|---|
| Sponsor | Algemeen Ziekenhuis Maria Middelares |
| Drug class | Catecholamine vasopressor |
| Target | Alpha-1 adrenergic receptor, Beta-1 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Norepinephrine acts as both a neurotransmitter and hormone, stimulating alpha-1 adrenergic receptors to cause vasoconstriction and beta-1 adrenergic receptors to increase cardiac output and heart rate. It is used clinically as a vasopressor agent to restore and maintain blood pressure in acute hypotensive states by increasing peripheral vascular resistance and myocardial contractility.
Approved indications
- Acute hypotension and shock (septic, cardiogenic, hypovolemic)
- Maintenance of blood pressure during anesthesia
Common side effects
- Hypertension
- Tachycardia
- Arrhythmias
- Headache
- Anxiety
- Tissue necrosis at infusion site
Key clinical trials
- Goal-directed Fluid Therapy During Deep Inferior Epigastric Perforator (DIEP) Free Flap Breast Reconstruction (PHASE4)
- Comparison of Conventional Fluid Management Protocol With Targeted Pleth Variability Index (PVI) Monitoring Protocol During Total Abdominal Hysterectomy and Bilateral Salpingooferectomy Operation (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Norepinephrine (static group) CI brief — competitive landscape report
- Norepinephrine (static group) updates RSS · CI watch RSS
- Algemeen Ziekenhuis Maria Middelares portfolio CI