{"id":"norepinephrine-static-group","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Arrhythmias"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Anxiety"},{"rate":null,"effect":"Tissue necrosis at infusion site"}]},"_chembl":{"chemblId":"CHEMBL432","moleculeType":"Small molecule","molecularWeight":"169.18"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Norepinephrine acts as both a neurotransmitter and hormone, stimulating alpha-1 adrenergic receptors to cause vasoconstriction and beta-1 adrenergic receptors to increase cardiac output and heart rate. It is used clinically as a vasopressor agent to restore and maintain blood pressure in acute hypotensive states by increasing peripheral vascular resistance and myocardial contractility.","oneSentence":"Norepinephrine is a catecholamine that binds to alpha and beta adrenergic receptors to increase heart rate, blood pressure, and cardiac contractility.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:41:46.768Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute hypotension and shock (septic, cardiogenic, hypovolemic)"},{"name":"Maintenance of blood pressure during anesthesia"}]},"trialDetails":[{"nctId":"NCT06080178","phase":"PHASE4","title":"Goal-directed Fluid Therapy During Deep Inferior Epigastric Perforator (DIEP) Free Flap Breast Reconstruction","status":"RECRUITING","sponsor":"Algemeen Ziekenhuis Maria Middelares","startDate":"2023-11-23","conditions":"Hypotension During Surgery","enrollment":82},{"nctId":"NCT04775576","phase":"NA","title":"Comparison of Conventional Fluid Management Protocol With Targeted Pleth Variability Index (PVI) Monitoring Protocol During Total Abdominal Hysterectomy and Bilateral Salpingooferectomy Operation","status":"COMPLETED","sponsor":"Dr. Lutfi Kirdar Kartal Training and Research Hospital","startDate":"2021-02-25","conditions":"Intraoperative Hypotension, Intraoperative Complications, Hypervolemia","enrollment":78}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Norepinephrine (static group)","genericName":"Norepinephrine (static group)","companyName":"Algemeen Ziekenhuis Maria Middelares","companyId":"algemeen-ziekenhuis-maria-middelares","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Norepinephrine is a catecholamine that binds to alpha and beta adrenergic receptors to increase heart rate, blood pressure, and cardiac contractility. Used for Acute hypotension and shock (septic, cardiogenic, hypovolemic), Maintenance of blood pressure during anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}