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Norepinephrine (dynamic group)
Norepinephrine is a catecholamine that binds to alpha and beta adrenergic receptors to increase heart rate, blood pressure, and cardiac contractility.
Norepinephrine is a catecholamine that binds to alpha and beta adrenergic receptors to increase heart rate, blood pressure, and cardiac contractility. Used for Acute hypotension and shock (septic, cardiogenic, hypovolemic), Maintenance of blood pressure during anesthesia.
At a glance
| Generic name | Norepinephrine (dynamic group) |
|---|---|
| Sponsor | Algemeen Ziekenhuis Maria Middelares |
| Drug class | Catecholamine vasopressor |
| Target | Alpha-1 adrenergic receptor, Beta-1 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Norepinephrine acts as both a neurotransmitter and hormone, stimulating alpha-1 adrenergic receptors to cause vasoconstriction and beta-1 adrenergic receptors to increase heart rate and contractile force. It is used clinically as a vasopressor agent to restore and maintain blood pressure in acute hypotensive states by increasing peripheral vascular resistance and cardiac output.
Approved indications
- Acute hypotension and shock (septic, cardiogenic, hypovolemic)
- Maintenance of blood pressure during anesthesia
Common side effects
- Hypertension
- Tachycardia
- Arrhythmias
- Headache
- Anxiety
- Tissue necrosis at injection site
Key clinical trials
- Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis (NA)
- Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome (PHASE3)
- Effect of Dynamic Arterial Elastance and Assisted Fluid Management Software Guided Resuscitation in Septic Shock: Pilot Study (NA)
- Evaluating Dynamic Arterial Elastance in Septic Shock Patients. (NA)
- Goal-directed Fluid Therapy During Deep Inferior Epigastric Perforator (DIEP) Free Flap Breast Reconstruction (PHASE4)
- Comparison of Conventional Fluid Management Protocol With Targeted Pleth Variability Index (PVI) Monitoring Protocol During Total Abdominal Hysterectomy and Bilateral Salpingooferectomy Operation (NA)
- The Stroke Volume Optimization of Goal Directed Fluid Therapy During Radical Cystectomy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Norepinephrine (dynamic group) CI brief — competitive landscape report
- Norepinephrine (dynamic group) updates RSS · CI watch RSS
- Algemeen Ziekenhuis Maria Middelares portfolio CI