{"id":"norepinephrine-dynamic-group","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Arrhythmias"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Anxiety"},{"rate":null,"effect":"Tissue necrosis at injection site"}]},"_chembl":{"chemblId":"CHEMBL432","moleculeType":"Small molecule","molecularWeight":"169.18"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Norepinephrine acts as both a neurotransmitter and hormone, stimulating alpha-1 adrenergic receptors to cause vasoconstriction and beta-1 adrenergic receptors to increase heart rate and contractile force. It is used clinically as a vasopressor agent to restore and maintain blood pressure in acute hypotensive states by increasing peripheral vascular resistance and cardiac output.","oneSentence":"Norepinephrine is a catecholamine that binds to alpha and beta adrenergic receptors to increase heart rate, blood pressure, and cardiac contractility.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:41:47.037Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute hypotension and shock (septic, cardiogenic, hypovolemic)"},{"name":"Maintenance of blood pressure during anesthesia"}]},"trialDetails":[{"nctId":"NCT07286643","phase":"NA","title":"Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis","status":"RECRUITING","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2026-01-01","conditions":"Cirrhosis, Liver, Cirrhotic Cardiomyopathy, Septic Shock","enrollment":140},{"nctId":"NCT07238465","phase":"PHASE3","title":"Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome","status":"NOT_YET_RECRUITING","sponsor":"University of Colorado, Denver","startDate":"2025-12","conditions":"Down Syndrome, Autonomic Dysfunction","enrollment":200},{"nctId":"NCT06937918","phase":"NA","title":"Effect of Dynamic Arterial Elastance and Assisted Fluid Management Software Guided Resuscitation in Septic Shock: Pilot Study","status":"RECRUITING","sponsor":"Mahidol University","startDate":"2025-04-23","conditions":"Critical Illness, Fluid Over-load, Dynamic Arterial Elastance","enrollment":60},{"nctId":"NCT06118775","phase":"NA","title":"Evaluating Dynamic Arterial Elastance in Septic Shock Patients.","status":"NOT_YET_RECRUITING","sponsor":"Fundación Santa Fe de Bogota","startDate":"2025-03-01","conditions":"Septic Shock","enrollment":114},{"nctId":"NCT06080178","phase":"PHASE4","title":"Goal-directed Fluid Therapy During Deep Inferior Epigastric Perforator (DIEP) Free Flap Breast Reconstruction","status":"RECRUITING","sponsor":"Algemeen Ziekenhuis Maria Middelares","startDate":"2023-11-23","conditions":"Hypotension During Surgery","enrollment":82},{"nctId":"NCT04775576","phase":"NA","title":"Comparison of Conventional Fluid Management Protocol With Targeted Pleth Variability Index (PVI) Monitoring Protocol During Total Abdominal Hysterectomy and Bilateral Salpingooferectomy Operation","status":"COMPLETED","sponsor":"Dr. Lutfi Kirdar Kartal Training and Research Hospital","startDate":"2021-02-25","conditions":"Intraoperative Hypotension, Intraoperative Complications, Hypervolemia","enrollment":78},{"nctId":"NCT03262480","phase":"NA","title":"The Stroke Volume Optimization of Goal Directed Fluid Therapy During Radical Cystectomy","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2017-09-01","conditions":"Radical Cystectomy","enrollment":172}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Norepinephrine (dynamic group)","genericName":"Norepinephrine (dynamic group)","companyName":"Algemeen Ziekenhuis Maria Middelares","companyId":"algemeen-ziekenhuis-maria-middelares","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Norepinephrine is a catecholamine that binds to alpha and beta adrenergic receptors to increase heart rate, blood pressure, and cardiac contractility. Used for Acute hypotension and shock (septic, cardiogenic, hypovolemic), Maintenance of blood pressure during anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}