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Nigella Sativa Oil
Nigella sativa oil exerts multi-target anti-inflammatory, antioxidant, and immunomodulatory effects through its active constituent thymoquinone and other phytochemicals.
Nigella sativa oil exerts multi-target anti-inflammatory, antioxidant, and immunomodulatory effects through its active constituent thymoquinone and other phytochemicals. Used for Inflammatory and autoimmune conditions (traditional use), Metabolic syndrome and diabetes (investigational), Respiratory and allergic conditions (traditional use).
At a glance
| Generic name | Nigella Sativa Oil |
|---|---|
| Also known as | Black seed Oil, Habbatussauda Oil MADINAH, Black seed oil capsule |
| Sponsor | University of Health Sciences Lahore |
| Drug class | Herbal extract / botanical supplement |
| Modality | Small molecule |
| Therapeutic area | Immunology, Inflammation, Metabolic disorders |
| Phase | FDA-approved |
Mechanism of action
Nigella sativa (black seed) oil contains thymoquinone and other bioactive compounds that suppress pro-inflammatory cytokines, reduce oxidative stress via free radical scavenging, and modulate immune cell function. The oil has demonstrated effects on NF-κB signaling inhibition and antioxidant enzyme upregulation in preclinical and clinical studies, contributing to its broad therapeutic potential across inflammatory and metabolic conditions.
Approved indications
- Inflammatory and autoimmune conditions
- Metabolic syndrome and diabetes
- Respiratory and allergic disorders
Common side effects
- Gastrointestinal upset
- Allergic reactions (rare)
Key clinical trials
- Prospective Randomized Controlled Pilot Study of Gut Microbiome Modulation by Nigella Sativa Seed Oil and Thymoquinone Metabolism in Healthy Volunteers (NA)
- Efficacy of Oral Nigella Sativa as Adjuvant Therapy in Children With Moderate Persistent Asthma (NA)
- Evaluation of a Nigella Sativa Extract (10% Thymoquinone, Nisatol®) in Perimenopausal Women With Metabolic Syndrome (NA)
- Omega-3, Nigella Sativa, Indian Costus, Quinine, Anise Seed, Deglycyrrhizinated Licorice, Artemisinin, Febrifugine on Immunity of Patients With (COVID-19) (PHASE2, PHASE3)
- NP-101 (TQ Formula) With Nivolumab and Ipilimumab in Advanced or Metastatic Extra-pulmonary Neuroendocrine Carcinomas (PHASE1)
- Effect Of Nigella Sativa Oil for the Treatment of Hypertension (NA)
- Effect of Black Cumin Seed Oil Supplementation on Cortisol, Stress and Mood (NA)
- Culinary Spices in Metabolic Syndrome. (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Nigella Sativa Oil CI brief — competitive landscape report
- Nigella Sativa Oil updates RSS · CI watch RSS
- University of Health Sciences Lahore portfolio CI