Last reviewed · How we verify
nicotine acid
Nicotine acid, also known as niacin, primarily functions by reducing the production of very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) cholesterol in the liver.
Nicotine acid, also known as niacin, primarily functions by reducing the production of very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) cholesterol in the liver. Used for Hypercholesterolemia, Mixed dyslipidemia.
At a glance
| Generic name | nicotine acid |
|---|---|
| Sponsor | GWT-TUD GmbH |
| Drug class | lipid-regulating agent |
| Target | GPR109A |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
It activates G protein-coupled receptors (GPCRs) such as GPR109A, which can lead to decreased hepatic synthesis of VLDL and increased HDL cholesterol levels, thereby improving lipid profiles.
Approved indications
- Hypercholesterolemia
- Mixed dyslipidemia
Common side effects
- Flushing
- Nausea
- Headache
Key clinical trials
- Orexin s Role in the Neurobiology of Substance Use Disorder (NA)
- Testing the Addition of Atezolizumab to Combination Chemotherapy or Atezolizumab Alone for Metastatic Colon or Rectal Cancer, the COMMIT Study (PHASE3)
- Exenatide for Smoking Cessation and Prevention of Weight Gain (PHASE2)
- THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension (NA)
- Effects of Commonly Used Medications on Mood and Choice (PHASE1)
- The Effects of Sedatives on Tobacco Use Disorder Version 2 (EARLY_PHASE1)
- Effect of the Thrive AI Health App on Lifestyle Behaviors and Quality of Life (NA)
- THRIVE Well Cancer FDTN/Exercise_Creatine Supplementation (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- nicotine acid CI brief — competitive landscape report
- nicotine acid updates RSS · CI watch RSS
- GWT-TUD GmbH portfolio CI