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Natrium picosulfate / Magnesium citrate
Natrium picosulfate / Magnesium citrate is a Stimulant laxative / osmotic laxative combination Small molecule drug developed by Tomas Bata Hospital, Czech Republic. It is currently FDA-approved for Bowel cleansing prior to colonoscopy or other colonic procedures, Constipation management.
Sodium picosulfate is a prodrug that is converted by colonic bacteria to bis-(p-hydroxyphenyl)-pyridyl-methane, which stimulates colonic contractions, while magnesium citrate acts as an osmotic laxative to retain water in the intestinal lumen.
Sodium picosulfate is a prodrug that is converted by colonic bacteria to bis-(p-hydroxyphenyl)-pyridyl-methane, which stimulates colonic contractions, while magnesium citrate acts as an osmotic laxative to retain water in the intestinal lumen. Used for Bowel cleansing prior to colonoscopy or other colonic procedures, Constipation management.
At a glance
| Generic name | Natrium picosulfate / Magnesium citrate |
|---|---|
| Sponsor | Tomas Bata Hospital, Czech Republic |
| Drug class | Stimulant laxative / osmotic laxative combination |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Sodium picosulfate undergoes bacterial metabolism in the colon to produce an active metabolite that directly stimulates colonic smooth muscle contractions, promoting bowel movement. Magnesium citrate functions as an osmotic agent, drawing water into the intestinal lumen to soften stool and increase intraluminal volume, thereby enhancing peristalsis. Together, these agents provide both stimulant and osmotic laxative effects for bowel cleansing.
Approved indications
- Bowel cleansing prior to colonoscopy or other colonic procedures
- Constipation management
Common side effects
- Abdominal pain or cramping
- Nausea
- Vomiting
- Diarrhea
- Headache
- Dizziness
Key clinical trials
- Polyethylene Glycol Versus Low Volume Solutions Prior to Colonoscopy (PHASE4)
- Comparison of Different Low Volume Solutions Prior to Colonoscopy (PHASE4)
- Impact of Time Intervals of Preparation on Quality and Tolerance of the Bowel Preparation (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Natrium picosulfate / Magnesium citrate CI brief — competitive landscape report
- Natrium picosulfate / Magnesium citrate updates RSS · CI watch RSS
- Tomas Bata Hospital, Czech Republic portfolio CI
Frequently asked questions about Natrium picosulfate / Magnesium citrate
What is Natrium picosulfate / Magnesium citrate?
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Related
- Drug class: All Stimulant laxative / osmotic laxative combination drugs
- Manufacturer: Tomas Bata Hospital, Czech Republic — full pipeline
- Therapeutic area: All drugs in Gastroenterology
- Indication: Drugs for Bowel cleansing prior to colonoscopy or other colonic procedures
- Indication: Drugs for Constipation management