{"id":"natrium-picosulfate-magnesium-citrate","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal pain or cramping"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL3989480","moleculeType":"Small molecule","molecularWeight":"451.11"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sodium picosulfate undergoes bacterial metabolism in the colon to produce an active metabolite that directly stimulates colonic smooth muscle contractions, promoting bowel movement. Magnesium citrate functions as an osmotic agent, drawing water into the intestinal lumen to soften stool and increase intraluminal volume, thereby enhancing peristalsis. Together, these agents provide both stimulant and osmotic laxative effects for bowel cleansing.","oneSentence":"Sodium picosulfate is a prodrug that is converted by colonic bacteria to bis-(p-hydroxyphenyl)-pyridyl-methane, which stimulates colonic contractions, while magnesium citrate acts as an osmotic laxative to retain water in the intestinal lumen.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:41:40.316Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel cleansing prior to colonoscopy or other colonic procedures"},{"name":"Constipation management"}]},"trialDetails":[{"nctId":"NCT02956057","phase":"PHASE4","title":"Polyethylene Glycol Versus Low Volume Solutions Prior to Colonoscopy","status":"COMPLETED","sponsor":"Tomas Bata Hospital, Czech Republic","startDate":"2016-11-12","conditions":"Colonoscopy","enrollment":1044},{"nctId":"NCT03698474","phase":"PHASE4","title":"Comparison of Different Low Volume Solutions Prior to Colonoscopy","status":"COMPLETED","sponsor":"Tomas Bata Hospital, Czech Republic","startDate":"2018-10-25","conditions":"Colonoscopy","enrollment":612},{"nctId":"NCT02908919","phase":"PHASE4","title":"Impact of Time Intervals of Preparation on Quality and Tolerance of the Bowel Preparation","status":"UNKNOWN","sponsor":"Faculty Hospital Kralovske Vinohrady","startDate":"2016-08","conditions":"Bowel Preparation, Colonoscopy","enrollment":480}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Natrium picosulfate / Magnesium citrate","genericName":"Natrium picosulfate / Magnesium citrate","companyName":"Tomas Bata Hospital, Czech Republic","companyId":"tomas-bata-hospital-czech-republic","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sodium picosulfate is a prodrug that is converted by colonic bacteria to bis-(p-hydroxyphenyl)-pyridyl-methane, which stimulates colonic contractions, while magnesium citrate acts as an osmotic laxative to retain water in the intestinal lumen. Used for Bowel cleansing prior to colonoscopy or other colonic procedures, Constipation management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}