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Native Vitamin D
Native Vitamin D acts as a ligand for the vitamin D receptor to regulate calcium and phosphate homeostasis and modulate immune function.
Native Vitamin D acts as a ligand for the vitamin D receptor to regulate calcium and phosphate homeostasis and modulate immune function. Used for Vitamin D deficiency, Hypocalcemia, Osteoporosis.
At a glance
| Generic name | Native Vitamin D |
|---|---|
| Sponsor | Xi'an Honghui Hospital |
| Drug class | Vitamin D supplement / Hormone |
| Target | Vitamin D receptor (VDR) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology / Bone metabolism / Immunology |
| Phase | FDA-approved |
Mechanism of action
Vitamin D, primarily in its active form (calcitriol or 1,25-dihydroxyvitamin D3), binds to the vitamin D receptor (VDR) in target tissues to promote intestinal calcium and phosphate absorption, maintain serum calcium levels, and regulate bone mineralization. Additionally, VDR activation modulates immune cell differentiation and function, contributing to both innate and adaptive immune responses.
Approved indications
- Vitamin D deficiency
- Hypocalcemia
- Osteoporosis
- Rickets
Common side effects
- Hypercalcemia
- Hypercalciuria
- Nausea
- Vomiting
- Constipation
Key clinical trials
- The Effect of REgulation of PArathyroId hoRmone in Patients With Chronic Kidney Disease to Investigate the Change in Bone Mineral Density (NA)
- Efficacy and Safety of Combination Denosumab With Eldecalcitol for Postmenopausal Women With Osteoporosis.(ESCORT) (PHASE4)
- A Clinical Trial Investigating the Effect of Salmon Bone Meal on Bone Mass Among Osteopenic Women (NA)
- A Study to Assess Efficacy of Supporting Properties and Safety of ARTNEO in Patients With Knee Osteoarthritis (NA)
- A Study to Investigate Efficacy and Safety With LEO 90100 Compared With Daivobet® Ointment in Adult Chinese Subjects With Stable Plaque Psoriasis (PHASE3)
- A Study of the Feasibility of Using the Dietary Supplement "ARTNEO" in Patients With Osteoathritis (NA)
- Vitamin D, Oxidative Stress and Inflammation in Hemodialysis (PHASE2, PHASE3)
- Effectiveness of Inactive Vitamin D Supplementation in Non-Alcoholic Fatty Liver Disease Patients (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |