{"id":"native-vitamin-d","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypercalcemia"},{"rate":null,"effect":"Hypercalciuria"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Constipation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Vitamin D, primarily in its active form (calcitriol or 1,25-dihydroxyvitamin D3), binds to the vitamin D receptor (VDR) in target tissues to promote intestinal calcium and phosphate absorption, maintain serum calcium levels, and regulate bone mineralization. Additionally, VDR activation modulates immune cell differentiation and function, contributing to both innate and adaptive immune responses.","oneSentence":"Native Vitamin D acts as a ligand for the vitamin D receptor to regulate calcium and phosphate homeostasis and modulate immune function.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:56:51.935Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vitamin D deficiency"},{"name":"Hypocalcemia"},{"name":"Osteoporosis"},{"name":"Rickets"}]},"trialDetails":[{"nctId":"NCT07171216","phase":"NA","title":"The Effect of REgulation of PArathyroId hoRmone in Patients With Chronic Kidney Disease to Investigate the Change in Bone Mineral Density","status":"RECRUITING","sponsor":"Herlev Hospital","startDate":"2025-11-20","conditions":"Chronic Kidney Disease Mineral and Bone Disorder","enrollment":70},{"nctId":"NCT05884372","phase":"PHASE4","title":"Efficacy and Safety of Combination Denosumab With 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Fatty Liver Disease","enrollment":100},{"nctId":"NCT04574323","phase":"NA","title":"Effects of a Paleolithic Lifestyle Intervention in Breast Cancer Patients Undergoing Radiotherapy","status":"COMPLETED","sponsor":"MVZ Leopoldina GmbH","startDate":"2020-03-19","conditions":"Breast Cancer, Body Weight Changes","enrollment":13},{"nctId":"NCT01939470","phase":"","title":"Oklahoma Native American Women's Osteoporosis Screening Study","status":"COMPLETED","sponsor":"Oklahoma State University","startDate":"2007-10","conditions":"Osteoporosis","enrollment":301},{"nctId":"NCT01817699","phase":"PHASE4","title":"Correcting Anemia and Native Vitamin D Supplementation in Kidney Transplant Recipients","status":"TERMINATED","sponsor":"CANDLE-KIT Trial Study Group","startDate":"2013-04","conditions":"Kidney Transplantation, Anemia, Vitamin D Deficiency","enrollment":161},{"nctId":"NCT03602430","phase":"PHASE2, PHASE3","title":"Cholecalciferol on Hemodialysis Patients","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2018-07-01","conditions":"Hemodialysis Complication, Vitamin D Deficiency, Vascular Calcification","enrollment":60},{"nctId":"NCT01490333","phase":"PHASE2","title":"Sunweavers: Supporting Native American Women's Vitamin D Research","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2011-07","conditions":"Vitamin D Deficiency, Cardiovascular Diseases","enrollment":99},{"nctId":"NCT01633658","phase":"NA","title":"The Variability of 25-hydroxyvitamin D Response From Crystalline 25-hydroxyvitamin D3","status":"WITHDRAWN","sponsor":"Creighton University","startDate":"2012-11","conditions":"Vitamin D Deficiency","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":137,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Native Vitamin D","genericName":"Native Vitamin D","companyName":"Xi'an Honghui Hospital","companyId":"xi-an-honghui-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Native Vitamin D acts as a ligand for the vitamin D receptor to regulate calcium and phosphate homeostasis and modulate immune function. Used for Vitamin D deficiency, Hypocalcemia, Osteoporosis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}