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Nanocrystalline silver
Nanocrystalline silver is a Antimicrobial agent Small molecule drug developed by University of Sorocaba. It is currently FDA-approved for Wound healing and infection prevention, Topical antimicrobial applications. Also known as: Acticoat.
Nanocrystalline silver exerts antimicrobial effects by releasing silver ions that disrupt bacterial cell membranes and inhibit microbial growth.
Nanocrystalline silver is a small molecule intervention used to study various conditions, including second-degree burns, wound infections, diabetic foot, pemphigus, and pemphigoid, in clinical trials. It is a silver-containing substance, as indicated by its synonyms in ChEMBL, which include silver nitrate and silver nitricum.
At a glance
| Generic name | Nanocrystalline silver |
|---|---|
| Also known as | Acticoat |
| Sponsor | University of Sorocaba |
| Drug class | Antimicrobial agent |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Wound Care |
| Phase | FDA-approved |
Mechanism of action
Silver nanoparticles have a high surface area-to-volume ratio, enabling efficient release of bactericidal silver ions. These ions interact with bacterial cell walls and membranes, disrupting their integrity and interfering with cellular respiration and DNA replication. The nanocrystalline formulation enhances bioavailability and antimicrobial potency compared to bulk silver.
Approved indications
- Wound healing and infection prevention
- Topical antimicrobial applications
Common side effects
- Local skin irritation
- Argyria (rare, with systemic absorption)
Key clinical trials
- Comparative Analysis of Cost-effectiveness of Silver Dressing in Burns (PHASE4)
- Diabetic Foot Ulcer Study on Topical Interventions (NA)
- Topical Silver for Prevention of Wound Infection After Cesarean Delivery (NA)
- Wound Dressings for Pemphigus and Pemphigoid (NA)
- A Comparison of Post-Sternotomy Dressings (NA)
- Preliminary Study of Safety and Efficacy of Nanocrystalline Silver Cream in Atopic Dermatitis (Eczema) (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Nanocrystalline silver CI brief — competitive landscape report
- Nanocrystalline silver updates RSS · CI watch RSS
- University of Sorocaba portfolio CI
Frequently asked questions about Nanocrystalline silver
What is Nanocrystalline silver?
How does Nanocrystalline silver work?
What is Nanocrystalline silver used for?
Who makes Nanocrystalline silver?
Is Nanocrystalline silver also known as anything else?
What drug class is Nanocrystalline silver in?
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What are the side effects of Nanocrystalline silver?
Related
- Drug class: All Antimicrobial agent drugs
- Manufacturer: University of Sorocaba — full pipeline
- Therapeutic area: All drugs in Infectious Disease / Wound Care
- Indication: Drugs for Wound healing and infection prevention
- Indication: Drugs for Topical antimicrobial applications
- Also known as: Acticoat
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing