{"id":"nanocrystalline-silver","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Argyria (rare, with systemic absorption)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Silver nanoparticles have a high surface area-to-volume ratio, enabling efficient release of bactericidal silver ions. These ions interact with bacterial cell walls and membranes, disrupting their integrity and interfering with cellular respiration and DNA replication. The nanocrystalline formulation enhances bioavailability and antimicrobial potency compared to bulk silver.","oneSentence":"Nanocrystalline silver exerts antimicrobial effects by releasing silver ions that disrupt bacterial cell membranes and inhibit microbial growth.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:56:45.104Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Wound healing and infection prevention"},{"name":"Topical antimicrobial applications"}]},"trialDetails":[{"nctId":"NCT02108535","phase":"PHASE4","title":"Comparative Analysis of Cost-effectiveness of Silver Dressing in Burns","status":"COMPLETED","sponsor":"University of Sorocaba","startDate":"2013-11","conditions":"Second-degree Burn","enrollment":100},{"nctId":"NCT02577900","phase":"NA","title":"Diabetic Foot Ulcer Study on Topical Interventions","status":"COMPLETED","sponsor":"Queen Elizabeth Hospital, Hong Kong","startDate":"2013-02","conditions":"Diabetic Foot","enrollment":31},{"nctId":"NCT01169064","phase":"NA","title":"Topical Silver for Prevention of Wound Infection After Cesarean Delivery","status":"TERMINATED","sponsor":"Vanderbilt University","startDate":"2010-07","conditions":"Wound Infection","enrollment":475},{"nctId":"NCT02365675","phase":"NA","title":"Wound Dressings for Pemphigus and Pemphigoid","status":"UNKNOWN","sponsor":"Fundación Nacional para la Enseñanza y la Investigación de la Dermatología A.C.","startDate":"2015-01","conditions":"Pemphigus, Pemphigoid","enrollment":12},{"nctId":"NCT02198066","phase":"NA","title":"A Comparison of Post-Sternotomy Dressings","status":"COMPLETED","sponsor":"Carilion Clinic","startDate":"2010-07","conditions":"Impaired Wound Healing, Postoperative Wound Infection-deep","enrollment":351},{"nctId":"NCT00076375","phase":"PHASE2","title":"Preliminary Study of Safety and Efficacy of Nanocrystalline Silver Cream in Atopic Dermatitis (Eczema)","status":"COMPLETED","sponsor":"Nucryst Pharmaceuticals","startDate":"2003-11","conditions":"Atopic Dermatitis, Eczema","enrollment":180}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":154,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Acticoat"],"phase":"marketed","status":"active","brandName":"Nanocrystalline silver","genericName":"Nanocrystalline silver","companyName":"University of Sorocaba","companyId":"university-of-sorocaba","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nanocrystalline silver is a small molecule intervention used to study various conditions, including second-degree burns, wound infections, diabetic foot, pemphigus, and pemphigoid, in clinical trials. It is a silver-containing substance, as indicated by its synonyms in ChEMBL, which include silver nitrate and silver nitricum.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}